2026-10-11T21:18:29Z
https://api.figshare.com/v2/oai
oai:figshare.com:article/34026547
2026-09-29T17:32:29Z
category_7
category_15
category_45
category_132
portal_5
item_type_3
month_year_09_2026
<p>Baseline and clinical characteristics.</p>
Kiran Roest (25138366)
Catherine Kelly (37020)
Tracy Marshall (6562717)
Emily Whales (25138369)
Lisa Taylor (3827440)
Rachel Hatfield (25138372)
Kate Bunyan (25138375)
Luke Dawson (18506616)
Steve Roest (25138378)
Julia Newton (840150)
Medicine
Neuroscience
Sociology
Infectious Diseases
main outcome measures
hypertension management services
deliver improved clinical
world communities across
high (> 5
weight loss services
total serum cholesterol
screened individuals ).
cohorts comprised 1
elevated cardiovascular risk
targeted outreach sub
xlink "> proof
weight loss
targeted outreach
xlink ">
high risk
workplace sub
cardiovascular disease
world cohort
united kingdom
systematic follow
smoking cessation
qrisk3 scores
lowering therapy
identify people
healthy heart
ethnically diverse
economic analyses
controlled studies
based point
0 mmol
<div>
<p>Objectives</p><p>To evaluate the proof-of-concept feasibility of identifying individuals at high risk of cardiovascular disease through community-based PocDoc Healthy Heart point-of-care screening in a large, ethnically diverse, disadvantaged real-world cohort in the United Kingdom.</p>
<p>Methods</p><p>Proof-of-concept, non-randomised, non-interventional real-world cardiovascular disease risk case finding study in adults aged 18 years or older in real-world communities across the United Kingdom. Main outcome measures were identification of individuals with high risk of cardiovascular disease, defined as QRISK3 score ≥10%; and individuals meeting the criteria for weight loss, smoking cessation, or hypertension management services.</p>
<p>Results</p><p>A total of 4,256 individuals (mean age 49 years, 57% male, 31% body mass index ≥30 kg/m<sup>2</sup>) were included in the Primary Cohort. The Targeted Outreach and Workplace sub-cohorts comprised 1,970 and 756 individuals, respectively. In the Primary Cohort, 35% (1,486/4,256) had high (>5.0 mmol/L) total serum cholesterol, 10% were smokers, 10% met criteria for weight loss services and 19% met criteria for hypertension management services. QRISK3 scores were generated for individuals who had not previously had a cardiovascular disease event (~90% of screened individuals). A QRISK3 score ≥10% was found in 20% (784/3,842) of individuals in the Primary Cohort, 26% (457/1,743) in the Targeted Outreach sub-cohort, and 6% (41/701) in the Workplace sub-cohort. In the Primary Cohort, 60% (472/784) of individuals with a QRISK3 score ≥10% were not being treated with a lipid-lowering therapy at the time of testing.</p>
<p>Conclusions</p><p>In this proof-of-concept study, community-based point-of-care screening identified individuals with elevated cardiovascular risk and unmet cardiovascular risk management needs. These findings are hypothesis-generating and provide the rationale for further controlled studies with systematic follow-up and health-economic analyses to evaluate whether this approach can deliver improved clinical and system-level outcomes.</p>
<p>Trial registration</p><p>ClinicalTrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT06258005" target="_blank">NCT06258005</a></p></div>
2026-09-29T17:32:21Z
Dataset
Dataset
10.1371/journal.pone.0358999.t001
https://figshare.com/articles/dataset/_p_Baseline_and_clinical_characteristics_p_/34026547
CC BY 4.0