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oai:figshare.com:article/34026478 2026-09-29T17:40:05Z category_1 category_12 category_15 category_272 category_734 category_811 category_61 category_122 portal_5 item_type_1 month_year_09_2026

<p>Sensorimotor–association timescale differentiation in HCPD.</p> Golia Shafiei (3191169) Joëlle Bagautdinova (25138348) Valerie J. Sydnor (25138351) Dani S. Bassett (13104131) Deanna M. Barch (6759263) Matthew Cieslak (3112521) Yong Fan (212624) Elizabeth Flook (25138354) Alexandre R. Franco (6564785) Gregory Kiar (785219) Audrey C. Luo (25138357) Michael P. Milham (8895014) Linden Parkes (6617396) Taylor Salo (5277443) Leah H. Somerville (5352008) Tien T. Tong (25138360) Russell T. Shinohara (9019436) Theodore D. Satterthwaite (11006319) Biophysics Cell Biology Neuroscience Environmental Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Developmental Biology Mental Health two independent cross spontaneous neural dynamics results reveal convergence commonly used measure hierarchical brain maturation independent developmental samples div >< p intrinsic timescale follow intrinsic timescale evolves intrinsic timescale displays highlighting intrinsic timescale human brain development sensorimotor cortex compared axis spanning sensorimotor adulthood </ p intrinsic timescale hierarchical pattern developmental patterns developmental findings association cortex n </ temporal window shorter timescales sectional datasets principled marker neuronal populations neurodevelopmental patterns major axes imaging modalities cortical organization axis ). association cortices <p>We tested whether timescale differentiation between sensorimotor and association regions increased with age. <b>(a)</b> In a within-subject distance-based analysis, cortical regions were divided into lower-ranking sensorimotor and higher-ranking association regions based on their position along the S–A axis. For each participant, pairwise timescale differences were computed within sensorimotor/association regions and across sensorimotor-to-association regions. Across-hierarchy differences were compared to within-hierarchy differences using a two-sample <i>t</i> test, generating a subject-level estimate of timescale differentiation. This measure showed a significant positive association with age using a GAM (partial <i>R</i>² = 0.025, <i>p</i>_anova = 0.0007). <b>(b)</b> In a complementary analysis, sensorimotor and association timescale values were directly compared within each participant using a two-sample <i>t</i> test. The resulting subject-level <i>t</i>-values also showed a significant positive association with age using a GAM (partial <i>R</i>² = 0.026, <i>p</i>_anova = 9.36 × 10⁻⁵). Each data point represents an individual participant. GAM fits are shown with black lines. Data and code needed to regenerate this figure can be found at <a href="https://doi.org/10.5281/zenodo.22799416" target="_blank">https://doi.org/10.5281/zenodo.22799416</a>.</p> <p>(TIFF)</p> 2026-09-29T18:01:47Z Image Figure 10.1371/journal.pbio.3004037.s001 https://figshare.com/articles/figure/_p_Sensorimotor-association_timescale_differentiation_in_HCPD_p_/34026478 CC BY 4.0