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oai:figshare.com:article/34026460 2026-09-29T17:31:33Z category_4 category_12 category_13 category_14 category_15 category_16 category_873 category_39 category_106 category_46 category_61 category_122 category_135 portal_5 item_type_1 month_year_09_2026

<p>NHR-68 RNAi inhibits pathogen avoidance behavior via the chemosensory neuron AWC.</p> Jie Ren (176083) Yu Sang (2551267) Young-Mo Kim (287055) Ernesto S. Nakayasu (156378) Alejandro Aballay (51596) Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Ecology Science Policy Immunology Developmental Biology Mental Health Computational Biology polyunsaturated fatty acid div >< p caenorhabditis elegans </ brain transcriptional circuit enhances pathogen avoidance 68 suppresses activation la restores avoidance avoidance circuit dependent pathogen 3 </ 2 </ p38 mapk neuron communication la synthesis immune outputs foxo pathways findings identify elevates la behavioral immunity 68 acts <p><b>(A)</b><i>P. aeruginosa</i> occupancy indexes of WT and AWC(−) animals fed empty vector control or <i>nhr-68</i> RNAi at 8 h and 12 h. <b>(B)</b> <i>P. aeruginosa</i> occupancy index for WT and AWB(−) animals fed empty vector control or <i>nhr-68</i> RNAi at 8 h and 12 h. <b>(C)</b> <i>P. aeruginosa</i> occupancy index of WT and ASI(−) animals fed empty vector control or <i>nhr-68</i> RNAi at 8 h and 12 h. <b>(D)</b> <i>P. aeruginosa</i> occupancy index of WT and ASE(−) animals fed empty vector control or <i>nhr-68</i> RNAi at 8 hr and 12 hr. <b>(E–H)</b> <i>P. aeruginosa</i> occupancy indexes at 8 h and 12 h for WT and sensory neuron-ablated animals treated with vehicle or LA. Each panel includes WT animals and one neuron-ablated strain: <b>(E)</b> AWC(−), <b>(F)</b> AWB(−), <b>(G)</b> ASI(−), or <b>(H)</b> ASE(−). LA, linoleic acid. The means and SDs of three independent experiments are shown; the bars, indicated by solid black horizontal lines within the violin plots, represent the means, and the error bars, indicated by thin horizontal lines within the violin plots, represent the SD. Data are presented as mean ± SD from three independent experiments (<i>N</i> = 3; <i>n</i> = 90 animals per condition per experiment). *<i>p</i> < 0.05, **<i>p</i> < 0.01, ***<i>p</i> < 0.001, and ns = not significant. The data underlying this Figure can be found in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3004026#pbio.3004026.s009" target="_blank">S1 Data</a>.</p> 2026-09-29T17:57:38Z Image Figure 10.1371/journal.pbio.3004026.g005 https://figshare.com/articles/figure/_p_NHR-68_RNAi_inhibits_pathogen_avoidance_behavior_via_the_chemosensory_neuron_AWC_p_/34026460 CC BY 4.0