2026-10-11T02:27:51Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026442 2026-09-29T17:31:26Z category_4 category_12 category_13 category_14 category_15 category_16 category_873 category_39 category_106 category_46 category_61 category_122 category_135 portal_5 item_type_3 month_year_09_2026

<p>Raw data.</p> Jie Ren (176083) Yu Sang (2551267) Young-Mo Kim (287055) Ernesto S. Nakayasu (156378) Alejandro Aballay (51596) Biochemistry Cell Biology Genetics Molecular Biology Neuroscience Physiology Chemical Sciences not elsewhere classified Ecology Science Policy Immunology Developmental Biology Mental Health Computational Biology polyunsaturated fatty acid div >< p caenorhabditis elegans </ brain transcriptional circuit enhances pathogen avoidance 68 suppresses activation la restores avoidance avoidance circuit dependent pathogen 3 </ 2 </ p38 mapk neuron communication la synthesis immune outputs foxo pathways findings identify elevates la behavioral immunity 68 acts <div><p>Animals must allocate limited energetic resources across competing defense programs in response to infection. Here, we show that the conserved nuclear hormone receptor NHR-68 integrates fatty acid metabolism with the neural control of molecular and behavioral immunity in <i>Caenorhabditis elegans</i>. Acting in parallel with NHR-10, NHR-68 controls genes involved in polyunsaturated fatty acid (PUFA) metabolism. Loss of NHR-68 disrupts linoleic acid (LA) homeostasis, impairing pathogen avoidance behavior. Supplementation with LA restores avoidance, and <i>fat-3</i> inhibition, which elevates LA, enhances pathogen avoidance, whereas loss of LA synthesis by <i>fat-2</i> inhibition diminishes this behavior, indicating that LA promotes behavioral immunity. We further show that NHR-68 acts in the intestine to regulate linoleic acid homeostasis, and that changes in intestinal lipid metabolism influence an AWC-dependent pathogen-avoidance circuit through intestine-to-neuron communication. NHR-68 suppresses activation of the PMK-1/p38 MAPK and DAF-16/FOXO pathways, which mediate molecular immune responses. These findings identify a gut-brain transcriptional circuit that connects intestinal lipid metabolism to neural and immune outputs, revealing a mechanism by which the metabolic state coordinates behavioral and molecular defenses to optimize host protection.</p></div> 2026-09-29T17:57:38Z Dataset Dataset 10.1371/journal.pbio.3004026.s009 https://figshare.com/articles/dataset/_p_Raw_data_p_/34026442 CC BY 4.0