2026-10-14T02:35:50Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026373 2026-09-29T17:30:13Z category_1 category_4 category_12 category_14 category_15 category_21 category_24 category_45 category_61 category_64 category_132 category_133 portal_5 item_type_1 month_year_09_2026

<p>Occurrence of individual diffusion states in labeled G proteins.</p> Ondřej Kuchynka (25138312) Andrei Kovalchuk (25138315) Mia Nußbaumer (25138318) Ekaterina Sviridova (25138321) Tomáš Fessl (25138324) Alexey Bondar (665062) Biophysics Biochemistry Cell Biology Molecular Biology Neuroscience Biotechnology Evolutionary Biology Sociology Developmental Biology Cancer Infectious Diseases Plant Biology remain poorly understood physical signals downstream many biophysical aspects key signal transducers findings identify subtype div >< p amplify extracellular chemical g &# 945 specific mobility differences subunits exhibit subtype heterotrimeric g proteins including membrane mobility g proteins membrane mobility g protein plasma membrane xlink "> using single subunit plays signaling dynamics results indicate molecule imaging major role live cells inner leaflet eukaryotic cells different subtypes coupled receptors </ sub <p>A) Fractions of immobile molecules (blue) and molecule tracks exhibiting confined (green), free (red), and directed diffusion (purple). Additionally, fractions of molecule tracks exhibiting restricted (immobile molecules and confined diffusion, diagonal line pattern) and non-restricted movement (free and directed diffusion, dotted pattern) are shown. B) Box plots of relative frequency of non-restricted movement in labeled G_s (yellow), G₁₂ (light blue), G₁₃ (dark blue), G_i1 (red), G_o (orange), G_q (magenta), and G_nat (green). The boxes indicate the median and the interquartile range. Letters above individual datasets indicate similarity grouping based on statistical analysis (<i>α</i> = 0.05, <i>p</i> < 0.0001, <i>H</i> = 67.59, <i>ε</i>^<i>2</i> = 0.62).</p> 2026-09-29T17:29:54Z Image Figure 10.1371/journal.pone.0359304.g004 https://figshare.com/articles/figure/_p_Occurrence_of_individual_diffusion_states_in_labeled_G_proteins_p_/34026373 CC BY 4.0