2026-10-14T15:52:59Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026343 2026-09-29T17:30:01Z category_1 category_4 category_12 category_14 category_15 category_21 category_24 category_45 category_61 category_64 category_132 category_133 portal_5 item_type_6 month_year_09_2026

<p>Membrane density and mobility in G protein heterotrimers.</p> Ondřej Kuchynka (25138312) Andrei Kovalchuk (25138315) Mia Nußbaumer (25138318) Ekaterina Sviridova (25138321) Tomáš Fessl (25138324) Alexey Bondar (665062) Biophysics Biochemistry Cell Biology Molecular Biology Neuroscience Biotechnology Evolutionary Biology Sociology Developmental Biology Cancer Infectious Diseases Plant Biology remain poorly understood physical signals downstream many biophysical aspects key signal transducers findings identify subtype div >< p amplify extracellular chemical g &# 945 specific mobility differences subunits exhibit subtype heterotrimeric g proteins including membrane mobility g proteins membrane mobility g protein plasma membrane xlink "> using single subunit plays signaling dynamics results indicate molecule imaging major role live cells inner leaflet eukaryotic cells different subtypes coupled receptors </ sub <p>Representative images of G_s (A), G₁₂ (B), G₁₃ (C), G_i1 (D), G_o (E), G_q (F), and G_nat (G) expressing cells. The scale bar in A-G is 10 µm. H) Linear regression fit illustrating the relationship between the mobility and membrane density of labeled Gγ₂-containing heterotrimers. Due to low sample size, no statistical inference was performed on these values. I) Linear regression analysis of the correlation between the mobility and membrane density of labeled Gγ₂-containing heterotrimers adjusted for group identity through residual analysis (slope = −0.009, 95% CI: −0.203 to 0.186; <i>R</i>² = < 0.001; <i>F</i>(1, 104) = 0.008; <i>p</i> = 0.928; <i>n</i> = 106).</p> <p>(PDF)</p> 2026-09-29T17:29:54Z Text Journal contribution 10.1371/journal.pone.0359304.s005 https://figshare.com/articles/journal_contribution/_p_Membrane_density_and_mobility_in_G_protein_heterotrimers_p_/34026343 CC BY 4.0