2026-10-13T11:47:02Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026327 2026-09-29T17:29:53Z category_7 category_12 category_13 category_14 category_61 category_62 category_64 category_122 category_132 portal_5 item_type_3 month_year_09_2026

<p>Multivariate survival analysis.</p> Kohei Matsuoka (3692662) Yuichiro Miki (5754011) Ryota Kawai (11312898) Masaki Nishiyama (17264159) Yuki Seki (4988693) Kenji Kuroda (5754017) Hiroaki Kasashima (656226) Mami Yoshii (8307636) Tatsuro Tamura (7841207) Masatsune Shibutani (765415) Takahiro Toyokawa (765421) Ayumi Shintani (11873) Kiyoshi Maeda (765416) Medicine Cell Biology Genetics Molecular Biology Developmental Biology Marine Biology Cancer Mental Health Infectious Diseases rapidly aging population optimize treatment strategies major complication group kaplan &# 8211 01 &# 8211 multivariate analysis showed meier analysis showed subgroup analysis study showed &# 8220 xlink "> underwent gastrectomy study aimed significantly worse scale studies postoperative complications poorer os hr 2 gastric cancer future large classified according ci 1 baseline characteristics 80 years 3 %), 063 ), 049 ). 004 ). <div> <p>Background</p><p>Japan’s rapidly aging population has led to an increase in elderly patients undergoing gastrectomy for gastric cancer. However, the impact of postoperative complications on survival in patients aged ≥80 years remains unclear. This study aimed to evaluate the association between postoperative complications and survival outcomes in patients aged ≥80 years with gastric cancer.</p> <p>Materials and methods</p><p>We retrospectively analyzed 61 patients aged ≥80 years who underwent gastrectomy with D2 lymph node dissection between 1999 and 2020. Postoperative complications were classified according to the Clavien-Dindo (CD) classification into a “no or minor complication group” (CD Grade ≤ II, including no postoperative complications) and a “major complication group” (CD Grade ≥ III), and the impact of postoperative complications on survival outcomes were assessed. A subgroup analysis excluding macroscopic type 4 was also performed.</p> <p>Results</p><p>Postoperative complications occurred in 24 patients (39.3%), of which 8 (13.1%) experienced major complications. Patients in the major complication group had a significantly longer postoperative hospital stay, while other baseline characteristics were similar between groups. Kaplan–Meier analysis showed a trend toward poorer OS in the major complication group (P = 0.063), and recurrence-free survival (RFS) was significantly worse in this group (P = 0.004). Multivariate analysis showed that postoperative complications of CD grade ≥ III were independently associated with poorer OS (HR 2.51; 95% CI 1.01–6.24; P = 0.049). Subgroup analysis in patients without type 4 also showed significantly worse OS in the major complication group (P = 0.036).</p> <p>Conclusion</p><p>This study showed that postoperative complications were associated with poorer OS and RFS even in patients aged ≥80 years with gastric cancer. Future large-scale studies are needed to further clarify this association and optimize treatment strategies for this population.</p></div> 2026-09-29T17:29:42Z Dataset Dataset 10.1371/journal.pone.0359100.t003 https://figshare.com/articles/dataset/_p_Multivariate_survival_analysis_p_/34026327 CC BY 4.0