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<p><i>evm.TU.LG18.404</i> encodes a fish-specific HECT E3 ubiquitin ligase.</p>
Juhong Xie (25138306)
Jiayi Lei (7853165)
Qinxue Zhu (25138309)
Bin Gui (542725)
Yongming Li (584924)
Yaping Wang (289641)
Rong Huang (298496)
Microbiology
Genetics
Molecular Biology
Environmental Sciences not elsewhere classified
Ecology
Immunology
Biological Sciences not elsewhere classified
Science Policy
Mental Health
Infectious Diseases
Plant Biology
Virology
specific ubiquitin ligase
significant scientific importance
rare minnow (<
innate immune regulation
immunological arms race
grass carp reovirus
grass carp (<
achieve immune escape
gobiocypris rarus </
ctenopharyngodon idella </
virus promotes degradation
stimulated gene 15
gchd ), caused
>) hemorrhagic diseases
viruses exploit ubiquitination
host interferon response
div >< p
ubiquitination plays
hemorrhagic disease
gene encodes
degradation via
nhre3 </
gcrv ),
viral evasion
translational value
thereby exerting
taken together
serious threat
random mutagenesis
proteasome pathway
mechanism unique
may represent
linked polyubiquitination
diverse form
central role
catalyzing k48
antiviral mechanism
ancient origins
<p>(A) Phylogenetic tree of G2E3 protein sequences from fish and other species. The phylogenetic tree was constructed using the neighbor-joining method in MEGA software. The accession numbers for the G2E3 amino acid sequences of each species are as follows: <i>Chanodichthys erythropterus</i> XP_067250078.1; <i>Ctenopharyngodon idella</i> XP_048066262.1; <i>Anabarilius grahami</i> XP_069428.1; <i>Pseudocoregonus laevis</i> XP_067250078.1; <i>A</i>. <i>grahami</i> XP_026099905.1; <i>Megalobrama amblycephala</i> XP_048066262.1; <i>A</i>. <i>grahami</i> ROI69428.1; <i>Pseudorasbora parva</i> XP_067268633.1; <i>Phoxinus phoxinus</i> KAK7135471.1; <i>Labeo rohita</i> KAI2661412.1; <i>Sinocyclocheilus anshuiensis</i> XP_016360734.1; <i>Cyprinus carpio</i> KTF85257.1; <i>Carassius auratus</i> XP_026099905.1; <i>Carassius gibelio</i> XP_052459386.1; <i>Triplophysa tibetana</i> KAA0713717.1; <i>Drosophila pseudoobscura</i> XP_001354945.2; <i>Parasteatoda tepidariorum</i> XP_015912803.2; <i>Lissotriton helveticus</i> XP_078515543.1; <i>Lacerta agilis</i> XP_033000160.1; <i>Gallus gallus</i> NP_001012918.2; <i>Mus musculus</i> NP_001015099.2; <i>Canis lupus familiaris</i> XP_013971289.1; <i>Sus scrofa</i> XP_001927828.4; <i>Homo sapiens</i> NP_060239.2; <i>Macaca mulatta</i> NP_001181581.2. (B) Comparison of G2E3 protein sequence similarity among fish and other species. Sequence similarity is markedly lower in fish than in other species. (C) Comparison of NHRE3, G2E3, and NEULR3 domains. The N-terminus of NHRE3 possesses a unique NHR domain.</p>
2026-09-29T17:29:22Z
Image
Figure
10.1371/journal.ppat.1014544.g001
https://figshare.com/articles/figure/_p_i_evm_TU_LG18_404_i_encodes_a_fish-specific_HECT_E3_ubiquitin_ligase_p_/34026286
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