2026-10-14T12:53:57Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34026265 2026-09-29T17:29:29Z category_8 category_13 category_14 category_272 category_39 category_46 category_734 category_106 category_122 category_132 category_133 category_134 portal_5 item_type_6 month_year_09_2026

<p>ISG15 and ISG152 are highly homologous.</p> Juhong Xie (25138306) Jiayi Lei (7853165) Qinxue Zhu (25138309) Bin Gui (542725) Yongming Li (584924) Yaping Wang (289641) Rong Huang (298496) Microbiology Genetics Molecular Biology Environmental Sciences not elsewhere classified Ecology Immunology Biological Sciences not elsewhere classified Science Policy Mental Health Infectious Diseases Plant Biology Virology specific ubiquitin ligase significant scientific importance rare minnow (< innate immune regulation immunological arms race grass carp reovirus grass carp (< achieve immune escape gobiocypris rarus </ ctenopharyngodon idella </ virus promotes degradation stimulated gene 15 gchd ), caused >) hemorrhagic diseases viruses exploit ubiquitination host interferon response div >< p ubiquitination plays hemorrhagic disease gene encodes degradation via nhre3 </ gcrv ), viral evasion translational value thereby exerting taken together serious threat random mutagenesis proteasome pathway mechanism unique may represent linked polyubiquitination diverse form central role catalyzing k48 antiviral mechanism ancient origins <p>(A) A comparison of the amino acid sequences of ISG15 and ISG152 reveals only three missense mutations (at positions 46aa, 48aa, and 50aa) and one synonymous mutation (at position 18aa). (B) COIP performed 24 hours after co-transfection of pcDNA-NHRE3-HA and pcDNA-ISG152-MYC in 293T cells revealed distinct bands in the NHRE3 and ISG152 IP fractions.</p> <p>(DOCX)</p> 2026-09-29T17:29:22Z Text Journal contribution 10.1371/journal.ppat.1014544.s005 https://figshare.com/articles/journal_contribution/_p_ISG15_and_ISG152_are_highly_homologous_p_/34026265 CC BY 4.0