2026-10-14T15:54:19Z
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2026-09-29T17:24:44Z
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<p>Correlation between ks-cfDNA and urine creatinine.</p>
Vanessa C. Heron (25138198)
John B. Whitlam (22153063)
David H. Murray (733029)
Nicky Boulter (3485630)
Peter Mount (4424851)
Suet-Wan Choy (335780)
Marina Katerelos (5782778)
Kathy Paizis (5782793)
Medicine
Cell Biology
Genetics
Pharmacology
Biotechnology
Mathematical Sciences not elsewhere classified
Developmental Biology
Marine Biology
Cancer
Virology
np participants (<
np controls (<
exploratory study found
centre prospective case
1 – 15
et quantities normalised
normotensive pregnant controls
20 np controls
specific epigenetic targets
quantify three kidney
urine creatinine demonstrated
3 – 5
urinary creatinine levels
versus 62 copies
represented total cfdna
cfdna showed non
et ): ks
59 – 0
cfdna quantities reflect
xlink "> cell
rptec marker ).
cfdna markers ks
preeclampsia </ p
urinary creatinine
absolute quantities
specific cell
xlink ">
versus 3
podocyte marker
normotensive pregnancies
including urine
20 women
urinary kidney
81 copies
231 copies
quantifying kidney
p </
kidney injury
cell death
047 ).
028 ).
005 ).
significant increases
predictive ability
organ injury
<p>Scatter plots showing relationships between urinary kidney-specific epigenetic targets (ks-et) and urine creatinine. (a-c) Each ks-et plotted against urine creatinine. A linear regression line is shown to illustrate the trend. (d) Urine creatinine versus total cell-free DNA (t-cfDNA), with t-cfDNA values plotted on a log<sub>10</sub>-scaled y-axis. (e-g) Fractional ks-et (%ks-et) plotted against urine creatinine. A linear regression line illustrates trend. Spearman’s correlation coefficient (ρ) and corresponding <i>P</i> values are shown for each plot. Each point represents an individual sample.</p>
2026-09-29T17:24:37Z
Image
Figure
10.1371/journal.pone.0359105.g003
https://figshare.com/articles/figure/_p_Correlation_between_ks-cfDNA_and_urine_creatinine_p_/34025695
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