2026-10-11T12:16:50Z
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2026-09-29T17:24:43Z
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<p>Comparison of ks-cfDNA quantities between groups.</p>
Vanessa C. Heron (25138198)
John B. Whitlam (22153063)
David H. Murray (733029)
Nicky Boulter (3485630)
Peter Mount (4424851)
Suet-Wan Choy (335780)
Marina Katerelos (5782778)
Kathy Paizis (5782793)
Medicine
Cell Biology
Genetics
Pharmacology
Biotechnology
Mathematical Sciences not elsewhere classified
Developmental Biology
Marine Biology
Cancer
Virology
np participants (<
np controls (<
exploratory study found
centre prospective case
1 – 15
et quantities normalised
normotensive pregnant controls
20 np controls
specific epigenetic targets
quantify three kidney
urine creatinine demonstrated
3 – 5
urinary creatinine levels
versus 62 copies
represented total cfdna
cfdna showed non
et ): ks
59 – 0
cfdna quantities reflect
xlink "> cell
rptec marker ).
cfdna markers ks
preeclampsia </ p
urinary creatinine
absolute quantities
specific cell
xlink ">
versus 3
podocyte marker
normotensive pregnancies
including urine
20 women
urinary kidney
81 copies
231 copies
quantifying kidney
p </
kidney injury
cell death
047 ).
028 ).
005 ).
significant increases
predictive ability
organ injury
<p>Tukey box-and-whisker plot comparing kidney-specific cell-free DNA (ks-cfDNA) between normotensive pregnant (NP) and preeclamptic (PE) groups. (a-c) Plots comparing the levels of urinary kidney-specific epigenetic targets (ks-et) and (d) total urinary cell-free DNA (t-cfDNA) between groups (copies/mL). (e-g) Each ks-et expressed as a percentage of t-cfDNA (%ks-et). Centre line denotes median value and box limits indicate 25<sup>th</sup> and 75<sup>th</sup> centiles. Whiskers extend to 1.5 x interquartile range (IQR). Points beyond whiskers represent outliers. Statistical significance was assessed using the Mann–Whitney U test. <i>P</i> values are shown.</p>
2026-09-29T17:24:37Z
Image
Figure
10.1371/journal.pone.0359105.g002
https://figshare.com/articles/figure/_p_Comparison_of_ks-cfDNA_quantities_between_groups_p_/34025692
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