2026-10-14T01:01:40Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34025595 2026-09-29T17:23:43Z category_4 category_7 category_12 category_14 category_16 category_46 category_61 category_62 category_64 category_132 portal_5 item_type_1 month_year_09_2026

<p>Representative cytokine alterations identified by antibody array analysis in RCC tissues.</p> Xu Chen (432759) Zhuangyao Liao (10320830) Rochelle Wickramasekara (25138173) Ying Luo (381053) Panning Wang (25138176) Sihao Wang (4577650) Yunru Chen (4351189) Hang Zhou (230977) Shuhong Luo (387711) Shaopeng Qiu (355114) Ruo-Pan Huang (303129) Biochemistry Medicine Cell Biology Molecular Biology Physiology Immunology Developmental Biology Marine Biology Cancer Infectious Diseases using antibody arrays remains poorly defined like receptor pathways invasive biomarker requiring common urological malignancy assessed using gepia analyzed via david tumors versus controls t2 metastatic tumors stage rcc may stage rcc patients urinary erbb3 emerged several cytokines correlated stage tumors rcc patients several cytokine selected cytokines related cytokines urinary erbb3 tumor tissues tumor microenvironment transcriptional expression timer databases survival outcomes stimulating factors serum levels related genes reduced immune poor survival meier plotter inflammatory signals improved outcomes immune infiltration functional enrichment findings suggest elevated pro cytokine signaling cytokine landscape candidate non also reduced 20 sets 174 tumor <p>(A) Representative antibody array membrane images from normal (left), para-cancerous (middle), and tumor (right) tissue samples analyzed using RayBio® Human Cytokine Antibody Arrays C6, C7, and C8. Colored boxes indicate the locations of representative cytokines shown in panel B. (B) Quantified signal intensities of representative cytokines identified from the antibody array dataset. Bar graphs show normalized cytokine expression levels in tumor, para-cancerous, and normal kidney tissue samples. Cytokines associated with angiogenesis and inflammatory signaling, including Angiopoietin-2, CCL4, RANTES/CCL5, and CXCL9, showed increased expression in tumor tissues, whereas IL-15, ErbB3, HGF, and FLT3LG showed decreased expression relative to control tissues. IL-2 showed a trend toward decreased expression in tumor tissues, although the difference did not reach statistical significance. Statistical significance annotations indicate comparisons among tissue groups as described in the Methods section. Statistical significance is indicated as follows: *P < 0.05, **P < 0.01, and ***P < 0.001.</p> 2026-09-29T17:23:34Z Image Figure 10.1371/journal.pone.0358533.g002 https://figshare.com/articles/figure/_p_Representative_cytokine_alterations_identified_by_antibody_array_analysis_in_RCC_tissues_p_/34025595 CC BY 4.0