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2026-09-29T17:22:31Z
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<p>Complexome profile of TOM40 and non-mitochondrial complexes.</p>
Andrew E. Maclean (10219517)
Orsola Iorillo (22772687)
Drahomíra Faktorová (373414)
Monika Singh (593097)
Suzanne McGill (11916067)
Julius Lukeš (122896)
Lilach Sheiner (79023)
Biochemistry
Microbiology
Cell Biology
Genetics
Evolutionary Biology
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
shares new components
mitoribosome possesses many
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highly conserved feature
perkinsus marinus </
divergent subunit composition
divergent mitochondrial complexes
perkinsus </
conserved across
toxoplasma </
plasmodium </
mitochondrial complexes
metc complexes
mitochondrial ribosome
mitochondrial function
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wider lineages
unexpected diversity
transcription factors
study reveals
outer membrane
observed enlarged
myzozoan parasite
metc ),
including members
deadly apicomplexan
complexome profiling
cell survival
atp synthase
apiap2 family
<p><i>(A)</i> Heatmap of the complexome profile from mitochondrially-enriched material of the TOM complex. Each row represents a gel slice, with the gel slice number indicated on the left and the molecular weight, based on the migration of mammalian mitochondrial complexes (black), on the right. Subunit IDs are shown at the bottom of their corresponding profile. Dark blue indicates the highest relative abundance (1) and white the lowest (0). Coomassie-stained Native PAGE gel on which the analysis was performed is depicted on the left of the profile. Data shown is from replicate 1. (B) Heatmap of the complexome profile from mitochondrially-enriched material of the 26S proteasome, comprised of the 19S regulatory particle (RP) and the 20S core particle (CP) as in part <i>(A)</i>. The molecular weight, based on the migration of soluble proteins (blue), is shown on the right. Data shown is from replicate 1. (C) Heatmap of the complexome profile from mitochondrially-enriched material of the Endoplasmic reticulum membrane protein complex (EMC), as in part <i>(A)</i>. Molecular weight is based on the migration of mammalian mitochondrial complexes (black). Data shown is from replicate 2.</p>
2026-09-29T17:22:05Z
Image
Figure
10.1371/journal.ppat.1014543.g005
https://figshare.com/articles/figure/_p_Complexome_profile_of_TOM40_and_non-mitochondrial_complexes_p_/34025473
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