2026-10-14T22:24:32Z
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2026-09-29T17:21:32Z
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<p>Associations between antidepressant class and individual antidepressant medications and special educational need.</p>
Saraid McIlvride (11979735)
Neha Rao (24389297)
Sarjit Singh (6491816)
Scott M. Nelson (8662176)
Jill P. Pell (7783655)
Michael Fleming (50815)
Medicine
Cell Biology
Biotechnology
Science Policy
Mental Health
norepinephrine reuptake inhibitors
markedly different association
level deprivation quintile
adjusted odds ratio
adjusted hazard ratio
447 children born
0 per 100
individual antidepressant classes
antidepressant medication without
antidepressant class showed
antidepressants may confer
although tricyclic antidepressants
meanwhile antidepressant use
recorded depression diagnosis
antidepressant medication exposure
xlink "> offspring
3 per 100
quantify absolute risk
mothers without depression
mean age 5
prenatal maternal depression
antidepressant use
antidepressant exposure
xlink ">
630 children
0 ])).
prenatal exposure
absolute risk
antidepressant prescriptions
maternal depression
higher risk
adhd diagnosis
maternal age
untreated depression
treated depression
depression severity
depression alone
two years
<p><b>A.</b> Generalized estimating equation (GEE) analysis; <b>B.</b> Cox proportional hazards analysis of associations between antidepressants and ADHD. Odds ratios/hazard ratios and 95% confidence intervals shown, for children exposed to treated depression compared to unexposed. Adjusted for sex, deprivation quintile, ethnicity, age, maternal age, maternal smoking status, parity, multiple birth and maternal epilepsy. For ADHD, ethnicity was collapsed into 4 categories (White; Black/Asian/Mixed; Other; Missing). SEN, special educational need; ASD, autism spectrum disorder; PMED, physical and medical difficulties; BES, behavioral-emotional-social; ADHD, attention deficit hyperactivity disorder; SSRIs, selective serotonin reuptake inhibitors; TCAs, tricyclic antidepressants; TeCAs, tetracyclic antidepressants; SNRIs, serotonin and norepinephrine reuptake inhibitors.</p>
2026-09-29T17:21:22Z
Image
Figure
10.1371/journal.pmed.1004658.g001
https://figshare.com/articles/figure/_p_Associations_between_antidepressant_class_and_individual_antidepressant_medications_and_special_educational_need_p_/34025398
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