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oai:figshare.com:article/34025034 2026-09-29T16:09:53Z category_1 category_4 category_146 category_7 category_8 category_14 category_21 category_873 category_39 category_62 category_128 category_135 portal_63 item_type_6 month_year_09_2026

Single-Atom Nickel-Catalyzed C–H Amidation of Pyridine and Quinoline N‑Oxides Yijie Jiang (3797206) Yanze Lu (19337374) Haijing Li (197338) Conghui Tang (1608868) Biophysics Biochemistry Space Science Medicine Microbiology Molecular Biology Biotechnology Chemical Sciences not elsewhere classified Ecology Marine Biology Hematology Computational Biology exafs analysis revealed efficient direct amidation commercially available quinoline heterogeneous nickel catalysis atom nickel catalyst 4 </ sub pharmaceutically relevant 2 atom nickel heterogeneous nature quinoline n work provides two one practical approach operational simplicity flexible preparation coordination environment catalytic system broad range aminoquinoline scaffolds also designed A single-atom nickel catalyst (Ni-N-C-700) was developed for the efficient direct amidation of quinoline N-oxides with dioxazolones, providing a broad range of 2-acetamidoquinoline N-oxide derivatives. Two one-pot synthetic routes starting from commercially available quinoline were also designed, enabling the flexible preparation of both 2-acetamidoquinoline N-oxides and the pharmaceutically relevant 2-aminoquinoline scaffolds. The single-atom nickel catalyst showed good stability, recyclability, and operational simplicity, while EXAFS analysis revealed a well-defined Ni–N₄ coordination environment. A hot filtration experiment confirmed the heterogeneous nature of the catalytic system. This work provides a practical approach to the 2-acetamidoquinoline N-oxide and further illustrates the utility of heterogeneous nickel catalysis in C–H functionalization reactions. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03895.s001 https://figshare.com/articles/journal_contribution/Single-Atom_Nickel-Catalyzed_C_H_Amidation_of_Pyridine_and_Quinoline_N_Oxides/34025034 CC BY-NC 4.0