2026-10-06T08:30:52Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34024649 2026-09-29T15:00:12Z category_4 category_272 category_873 portal_63 item_type_6 month_year_09_2026

Palladium-Catalyzed Directed Asymmetric C–H Arylation Leading to a P‑Stereogenic Center Shengzhou Jin (5847233) Mohammad Khavani (1976671) Yu Wang (12152) Ankit Pandey (9179715) Qiyang Jiang (8755857) Sai Zhang (118714) Ruibin Liang (1858501) Guigen Li (1317591) Biochemistry Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified ray diffraction analysis phenolic hydroxyl functionality pd metal center enabling efficient access detailed experimental studies broad substrate scope efficient directing group stereogenic chiral compounds 30 distinct p oh group chiral ligand synergistic coordination reaction demonstrated excellent yields ee ). diverse array dft calculations carboxylic acid absolute configuration >)- 6 90 %) A novel -OH group-directed asymmetric catalytic C(sp²)–H arylation has been developed, enabling efficient access to P-stereogenic chiral compounds with excellent yields (up to 90%) and enantioselectivity (up to 98% ee). The success of this C–H functionalization system relies on the synergistic coordination of a phenolic hydroxyl functionality and (<i>S</i>)-6-oxopiperidine-2-carboxylic acid with the Pd metal center, which acts as the efficient directing group and chiral ligand. The reaction demonstrated a broad substrate scope, affording a diverse array of 30 distinct P-chiral products. The absolute configuration of the products was unambiguously confirmed via X-ray diffraction analysis. Furthermore, a plausible catalytic cycle mechanism has been proposed, which is supported by detailed experimental studies and DFT calculations. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03398.s001 https://figshare.com/articles/journal_contribution/Palladium-Catalyzed_Directed_Asymmetric_C_H_Arylation_Leading_to_a_P_Stereogenic_Center/34024649 CC BY-NC 4.0