2026-10-14T08:18:34Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34024586 2026-09-29T14:38:22Z category_1 category_4 category_8 category_16 category_873 category_39 category_69 category_133 category_135 portal_63 item_type_6 month_year_09_2026

Design of Experiments for Diverse Carbon Isotope Labeling with Aryl Thianthrenium Salts Vitus Juel Enemærke (25137461) Rasmus Steemann Grarup (25137464) Troels Skrydstrup (1314168) Biophysics Biochemistry Microbiology Physiology Chemical Sciences not elsewhere classified Ecology Inorganic Chemistry Plant Biology Computational Biology several pharmaceutical molecules key mechanistic insight ex situ </ aryl thianthrenium salts stage isotope labeling isotope labeling stoichiometric amounts labeled products carbonylation products broad range A method for accessing structurally diverse carbon-isotope-labeled products from aryl thianthrenium salts has been established. The use of near-stoichiometric amounts of <i>ex situ</i>-generated carbon monoxide along with simple, air-stable palladium catalysts allows for the synthesis and isotope labeling of a broad range of carbonylation products. Design of Experiments enabled rapid optimization and gain of key mechanistic insight. The reaction tolerates electronically diverse electrophiles and could be used for the synthesis and late-stage isotope labeling of several pharmaceutical molecules. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03866.s001 https://figshare.com/articles/journal_contribution/Design_of_Experiments_for_Diverse_Carbon_Isotope_Labeling_with_Aryl_Thianthrenium_Salts/34024586 CC BY-NC 4.0