2026-10-14T09:27:33Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34023821 2026-09-29T12:51:58Z category_4 category_7 category_272 category_873 category_734 category_64 category_106 category_128 portal_87 item_type_3 month_year_09_2026

Effects of the FADS1 rs174537 polymorphism on polyunsaturated fatty acid levels in human tissues: a systematic review Melissa Pontes Klippel Oliveira (25137137) Deysimara de Cássia Santos (25137140) Danielle Negri Ferreira Neves (25137143) Gisele Queiroz Carvalho (4925182) Biochemistry Medicine Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Cancer Science Policy Hematology FADS1 gene nutrigenetic omega-3 omega-6 polyunsaturated fatty acids <p>The rs174537 polymorphism of the FADS1 gene is identified as one of the main determinants of polyunsaturated fatty acid (PUFAs) levels. The objective of this systematic review was to synthesize and critically evaluate the evidence regarding the association between this single nucleotide polymorphism and PUFAs levels in blood, breast milk, and erythrocyte membranes. The study was conducted in accordance with the PRISMA guidelines and was registered in PROSPERO. Searches were performed in the PubMed/MEDLINE, Scopus, Embase, and Cochrane Library databases, resulting in the inclusion of 24 articles, which were assessed using Joanna Briggs Institute tools. The results demonstrated that, in all studied populations and human tissues, GT or TT individuals presented lower levels of long-chain products, such as acid arachidonic (ARA), acid eicosapentaenoic (EPA), and acid docosahexaenoic (DHA), compared to homozygous GG individuals. It is concluded that the rs174537 polymorphism is directly related to the levels of these lipids, and nutritional and supplementation recommendations should take this into consideration, suggesting a new perspective on personalized nutrition and nutrigenetics.</p> 2026-09-29T12:51:58Z Dataset Dataset 10.6084/m9.figshare.34023821.v1 https://figshare.com/articles/dataset/Effects_of_the_FADS1_rs174537_polymorphism_on_polyunsaturated_fatty_acid_levels_in_human_tissues_a_systematic_review/34023821 CC BY 4.0