2026-10-11T17:58:31Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34023777 2026-09-29T12:40:20Z category_4 category_146 category_7 category_12 category_14 category_19 category_21 category_61 category_106 category_135 portal_87 item_type_6 month_year_09_2026

A dual-action biotin nanogel for accelerated wound healing: a bioinspired approach to antioxidant and regenerative delivery Samaa Abdullah (20295517) Samar Thiab (10765768) Alaa A. Al-Masud (19370050) Sami H. Alonazi (25137051) Hatim S. AlKhatib (8969534) Imad Hamadneh (808711) Biochemistry Space Science Medicine Cell Biology Molecular Biology Pharmacology Biotechnology Developmental Biology Science Policy Computational Biology Wound healing biotin–coenzyme Q10 nanogel sodium alginate hydrogel transdermal drug delivery oxidative stress modulation angiogenesis and collagen regeneration <p>A biotin–coenzyme Q10–sodium alginate (BTN–CoQ10–SA) nanogel was developed for topical wound healing through combined antioxidant and regenerative delivery. The optimized nanogel showed a particle size of ∼115 nm, zeta potential of −35.1 mV, encapsulation efficiency of 88.3%, and sustained BTN release over 24 h. In a rat excisional wound model, the nanogel achieved 95.1% wound closure by day 14 and significantly outperformed the untreated control. Treatment also increased VEGF, collagen I, and TGF-β1 expression while reducing IL-6 levels. These findings demonstrate the potential of BTN–CoQ10–SA nanogels as a sustained topical system for promoting wound repair.</p> 2026-09-29T12:40:20Z Text Journal contribution 10.6084/m9.figshare.34023777.v1 https://figshare.com/articles/journal_contribution/A_dual-action_biotin_nanogel_for_accelerated_wound_healing_a_bioinspired_approach_to_antioxidant_and_regenerative_delivery/34023777 CC BY 4.0