2026-10-06T08:30:25Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34023540 2026-09-29T11:59:45Z category_25210 item_type_3 month_year_09_2026

Rebooting Cyclobutadiene Chemistry through Regiodivergent Functionalization Dorian Didier (18618496) Organic chemical synthesis Cyclobutadiene Functionalization Regioselectivity Metalation TMPLi <p dir="ltr">De novo design of cyclobutadiene-iron (CBD-Fe) complexes has allowed for the synthesis of new libraries of four-membered building blocks. The use of tetramethylpiperidinyllithium bases (TMP-Li) allows for smooth, yet highly selective metalation of those CBD-Fe complexes, providing efficient and unprecedented access to trisubstituted architectures. Perfect control of the regiochemical outcome was achieved by fine tuning of the nature of substituents, applying steric, coordinating and electronic effects during the metalation step.</p> 2026-09-29T11:59:45Z Dataset Dataset 10.6084/m9.figshare.34023540.v1 https://figshare.com/articles/dataset/Rebooting_Cyclobutadiene_Chemistry_through_Regiodivergent_Functionalization/34023540 CC BY 4.0