2026-10-14T02:36:27Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34023504 2026-09-29T11:45:31Z category_4 category_146 category_7 category_12 category_19 category_21 category_39 category_46 category_64 portal_87 item_type_3 month_year_09_2026

Uncovering the anti-inflammatory and anti-angiogenesis activities of sinensetin orally administered to arthritic mice: synthesis, in vivo and in vitro evaluation Abdulmenem Bakkouri (25136916) Mun Fei Yam (15993881) Chong-Yew Lee (25136919) Biochemistry Space Science Medicine Cell Biology Pharmacology Biotechnology Ecology Immunology Cancer Sinensetin rheumatoid arthritis anti-inflammatory anti-angiogenesis synthesis oral bioavailability Sinensetin, a prominent flavone from Orthosiphon stamineus is a promising constituent for anti-rheumatoid arthritis. This study evaluated the oral anti-inflammatory and anti-angiogenic efficacy of sinensetin. In carrageenan-induced arthritic mice, oral sinensetin (25–100 mg/kg) significantly reduced paw edema with dose-correlated plasma kinetics, confirming functional oral bioavailability despite a delayed onset compared to intraperitoneal administration. Ex vivo rat aortic ring and in vitro human endothelial assays revealed that sinensetin robustly suppressed microvessel outgrowth and cell migration via VEGF downregulation. These findings demonstrate that sinensetin is an orally bioavailable agent capable of suppressing inflammation and angiogenesis. 2026-09-29T11:45:31Z Dataset Dataset 10.6084/m9.figshare.34023504.v1 https://figshare.com/articles/dataset/Uncovering_the_anti-inflammatory_and_anti-angiogenesis_activities_of_sinensetin_orally_administered_to_arthritic_mice_synthesis_i_in_vivo_i_and_i_in_vitro_i_evaluation/34023504 CC BY 4.0