2026-10-07T19:52:00Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34023411 2026-09-30T00:56:51Z category_25198 portal_12 item_type_5 month_year_09_2026

Samantha Bottom: Special Delivery: Cell-Penetrating Peptides as VIP Couriers to the Fungal Cell Interior Samantha Bottom (25136812) Vijayalekshmi Sarojini (1684420) David Barker (1188534) Rebecca Deed (1211976) Medicinal and biomolecular chemistry not elsewhere classified medicinal chemistry antimicrobial fungi peptides synthesis biology <p dir="ltr">Fungal infections are becoming more deadly and difficult to treat due to the growing prevalence of antimicrobial resistance to currently available antifungal treatments. A major contributing factor to the decreased efficacy of some antifungals is the lack of successful drug entry into the cell. Therefore, new drug delivery methods are needed, such as cell-penetrating peptides (CPPs), which have demonstrated success in delivering antibacterial drug cargo into bacteria but have received limited research on their application in fungi.<br>In this research, antifungals are chemically connected to a CPP that acts as a VIP courier to deliver the antifungal drug parcel into the VIP location, the fungal cell. The biological activity and efficacy of this system is evaluated across various fungal species that infect plants and mammals. </p> 2026-09-30T00:56:51Z Image Poster 10.17608/k6.auckland.34023411.v2 https://figshare.com/articles/poster/Special_Delivery_Cell-Penetrating_Peptides_as_VIP_Couriers_to_the_Fungal_Cell_Interior/34023411 CC BY 4.0