2026-10-14T00:29:50Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34023156 2026-09-29T10:50:22Z category_7 category_21 category_46 category_135 portal_87 item_type_6 month_year_09_2026

Prevalence and Long-Term Incidence of Ocular Manifestations in Sarcoidosis: A Large Nationwide Population-Based Study Uria Shani (17859937) Yonatan Shneor Patt (17859949) Scott Ehrenberg (14599839) Yoav Elizur (13945617) Arnon D. Cohen (11824655) Howard Amital (24341) Niv Ben-Shabat (11888640) Medicine Biotechnology Immunology Computational Biology Cardiac sarcoidosis ocular sarcoidosis retinitis sarcoidosis uveitis <p>Ocular involvement causes major vision-threatening morbidity in sarcoidosis. Population-based evidence on the full ocular spectrum, long-term incidence, and organ-specific patterns remains limited.</p> <p>Nationwide 1:1 matched case-control study with a longitudinal retrospective cohort component, using the electronic health record (EHR) database of Clalit Health Services (CHS; Israel’s largest health organization), comprising 12 076 adults matched on age and sex. We examined prevalence and post-diagnosis incidence of all five principal ocular manifestations (uveitis, optic neuritis, glaucoma, retinitis, scleritis) using multivariable logistic and Cox regression, adjusted for demographics, lifestyle, and 8 comorbidities.</p> <p>All five ocular phenotypes were significantly more prevalent in sarcoidosis, most strikingly optic neuritis (adjusted odds ratio [aOR] 10.46, 95% confidence interval [CI] 2.44–44.88, <i>p</i> = 0.002) and uveitis (aOR 7.15, 95% CI 5.54–9.22, <i>p</i> < 0.001); any ocular manifestation aOR 3.03 (<i>p</i> < 0.001). Over a median 11.3-year follow-up, sarcoidosis was associated with increased risk of any ocular manifestation (adjusted hazard ratio [aHR] 2.44, 95% CI 2.00–2.97) and uveitis (aHR 6.65, 95% CI 4.72–9.38, <i>p</i> < 0.001). Incident glaucoma was not elevated (aHR 0.90, <i>p</i> = 0.472), suggesting that the cross-sectional excess largely reflects prevalent disease. In an exploratory within-case analysis, cardiac involvement was associated with retinitis (adjusted OR 4.35, 95% CI 1.50–12.66, <i>p</i> = 0.007), based on few events (37 retinitis cases) and requiring prospective validation. This pairing was the strongest organ-ocular signal observed.      </p> <p>Sarcoidosis was associated with elevated prevalence of all five ocular outcomes and increased incident uveitis risk; retinitis showed a directionally elevated but imprecise estimate, whereas glaucoma risk was not increased. The exploratory cardiac-retinitis association warrants prospective evaluation.</p> 2026-09-29T10:50:22Z Text Journal contribution 10.6084/m9.figshare.34023156.v1 https://figshare.com/articles/journal_contribution/Prevalence_and_Long-Term_Incidence_of_Ocular_Manifestations_in_Sarcoidosis_A_Large_Nationwide_Population-Based_Study/34023156 CC BY 4.0