2026-10-11T20:42:45Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34022970 2026-09-29T10:45:03Z category_19 portal_316 item_type_3 month_year_09_2026

Table 1_Case report: Butylphthalide-associated severe thrombocytopenia, a rare adverse drug reaction.docx Chenyi Gong (12471057) Xiaoling Feng (10909845) Yeqing Hu (3834166) Jian Wang (5901) Yanan Zhang (1322391) Xiaoyan Sun (28501) Bing Zhang (129) Ying Liu (18461) Hengya Zhu (25136664) Pharmacology butylphthalide case report cerebral infarction drug side effects thrombocytopenia Introduction<p>Butylphthalide (DL-NBP) is a widely used neuroprotective agent for acute ischemic stroke. Although generally well-tolerated, severe thrombocytopenia as a rare adverse reaction has not been fully recognized. Herein, we report a severe case of probable DL-NBP-associated thrombocytopenia to increase clinical awareness and inform clinical management.</p>Case Presentation<p>A 69-year-old male with hypertension was admitted for acute brainstem infarction. His hospitalization was complicated by catastrophic thrombocytopenia (min 1.0 × 10⁹/L), suggestive of a possible immune-mediated thrombocytopenia. Subsequent complications included hypoxemia, pneumonia, occult gastrointestinal blood loss, and muscular venous thrombosis of the right calf, creating complex management challenges. Through multidisciplinary collaboration, multimodal tailored treatment was delivered to balance the risks of stroke recurrence and bleeding: corticosteroids, platelet transfusion, recombinant human thrombopoietin and recombinant human interleukin-11 were administered for presumed immune-mediated thrombocytopenia, and antiplatelet therapy was sequentially modified. The patient’s condition stabilized with normalized platelet counts, and he was transferred for rehabilitation.</p>Conclusion<p>Severe thrombocytopenia showed a temporal association with DL-NBP treatment. After excluding alternative etiologies, probable DL-NBP-associated thrombocytopenia was considered in this case.</p> 2026-09-29T10:45:03Z Dataset Dataset 10.3389/fphar.2026.1903450.s001 https://figshare.com/articles/dataset/Table_1_Case_report_Butylphthalide-associated_severe_thrombocytopenia_a_rare_adverse_drug_reaction_docx/34022970 CC BY 4.0