2026-10-09T10:55:58Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34022870 2026-09-29T10:40:21Z category_37339 category_37354 category_37375 portal_1012 item_type_1 month_year_09_2026

Figure 2 from Improving Long-Read Somatic Structural Variant Calling with Pangenome and <i>De Novo</i> Personal Genome Assembly Qian Qin (25136621) Jakob M. Heinz (25136624) Heng Li (9531776) Cancer Molecular and Cellular Biology Methods and Technology Algorithms Computational Methods Software Genome Biology Structural genomics Sequence Analysis <p>Somatic SV calling on matched COLO829 tumor–normal cell lines. <b>A–D,</b> Metrics on <i>de novo</i> assembly-based filtering. <b>E–H,</b> Metrics on pangenome-based filtering. <b>A</b> and <b>E,</b> Number of FP and TP SV calls (<b>C</b> and <b>G</b>) from PacBio HiFi data at different cutoffs on supporting reads. The solid bars correspond to SV calls still observed in the alignment against the COLO829BL (derived from blood) assembly, whereas the shaded bars correspond to calls filtered by the assembly. The horizontal line gives the number of SV calls from Valle-Inclan and colleagues (<a target="_blank" href="#bib22">22</a>), which are taken as ground truth. <b>B</b> and <b>F,</b> Number of FP and TP calls (<b>D</b> and <b>H</b>) from ONT reads.</p> 2026-09-29T00:00:00Z Image Figure 10.1158/2767-9764.34022870 https://figshare.com/articles/figure/Figure_2_from_Improving_Long-Read_Somatic_Structural_Variant_Calling_with_Pangenome_and_i_De_Novo_i_Personal_Genome_Assembly/34022870 CC BY