2026-10-14T06:09:45Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34022000 2026-09-29T08:06:11Z category_1 category_4 category_8 category_12 category_21 category_873 category_46 category_734 category_931 category_69 portal_63 item_type_6 month_year_09_2026

Cobalt-Catalyzed Azidation of Benzylic C–H Bonds Peng-Fei Wang (1469590) Xiang Wang (127867) Yan-Qing Zeng (24143776) Bing-Fa Xiang (25136030) Li-Hua Zhao (300914) Jing Chen (4762) Xian-Heng Song (20585710) Ya-Jun Wang (137203) Biophysics Biochemistry Microbiology Cell Biology Biotechnology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Information Systems not elsewhere classified Inorganic Chemistry transformations remain challenging enables efficient access success lies selective functionalization reaction process reaction employs n </ limiting reagent group tolerance good functional complex molecules commercially available catalyzed azidation benzylic azides benzyl radical atom transfer >- ligand Direct methods for selective functionalization of C(sp³)–H bonds could greatly streamline the synthesis of complex molecules. However, such transformations remain challenging. Herein, we report a cobalt-catalyzed azidation of benzylic C–H bonds that enables efficient access to benzylic azides. The reaction employs the C–H substrate as the limiting reagent and features broad substrate scope, as well as good functional-group tolerance. The key to success lies in the utilization of a commercially available <i>N</i>,<i>N</i>-ligand and cobalt catalyst. Preliminary mechanistic study indicates that hydrogen-atom transfer (HAT) of benzylic C–H bonds affords a benzyl radical that is involved in the reaction process. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.joc.6c01153.s001 https://figshare.com/articles/journal_contribution/Cobalt-Catalyzed_Azidation_of_Benzylic_C_H_Bonds/34022000 CC BY-NC 4.0