2026-10-10T13:01:53Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34021782 2026-09-29T07:08:51Z category_1 category_4 category_146 category_21 category_873 category_931 category_61 category_64 portal_63 item_type_2 month_year_09_2026

In Situ Photocurable Janus Hydrogels with Magnetically Guided Anisotropic Conductivity for Myocardial Ischemeia–Reperfusion Injury Treatment and Tissue Adhesion Prevention Zheng Cao (562710) Tianzi Chen (113414) Xiaoling Fu (424240) Yingjun Wang (571234) Biophysics Biochemistry Space Science Biotechnology Chemical Sciences not elsewhere classified Information Systems not elsewhere classified Developmental Biology Cancer regulating local inflammation rapid ultraviolet cross promising therapeutic strategy photocurable janus hydrogels nonspecific tissue adhesion natural myocardial tissue form conductive pathways fold adhesion contrast enhancing signal propagation combining structural support alleviating oxidative stress adverse cardiac remodeling minimally invasive manner poor electrical integration neonatal rat cardiomyocytes 4 </ sub 3 </ sub situ </ italic situ </ electrical integration vitro </ invasive implantation uniformly cover traditional designs synchronous contraction reperfusion therapy often leading magnetic guidance injury remains heart failure functional maturation experiments showed biochemical regulation beating heart antioxidant activity antiadhesion interface anisotropic conductivity Myocardial ischemia–reperfusion (I/R) injury remains a major clinical challenge associated with reperfusion therapy, often leading to adverse cardiac remodeling and heart failure. Although cardiac patches offered a promising therapeutic strategy, the traditional designs had some limitations, such as invasive implantation, poor electrical integration, and nonspecific tissue adhesion. Here, we introduced an <i>in situ</i> photoinitiated Janus conductive hydrogel patch, namely, HD/G@Fe₃O₄-A, which integrates minimally invasive delivery, spatiotemporal programmed asymmetric adhesion, and magnetically guided anisotropic conductivity. This shear-thinning hydrogel precursor could be injected through a catheter and uniformly cover the beating heart and then achieve strong myocardial attachment on one side through rapid ultraviolet cross-linking while forming an antiadhesion interface on the other side, resulting in a 60- to 80-fold adhesion contrast. Under magnetic guidance, Fe₃O₄ microspheres were arranged to form conductive pathways, simulating the anisotropic conductivity of natural myocardial tissue and enhancing signal propagation and synchronous contraction. <i>In vitro</i> experiments showed that HD/G@Fe₃O₄-A exhibited excellent cell compatibility and antioxidant activity while promoting the functional maturation of neonatal rat cardiomyocytes. In a rat I/R model, the patch significantly improved cardiac function by effectively restoring electrophysiological conduction and alleviating oxidative stress, thereby reducing ventricular dilation and fibrosis. Moreover, it prevented postoperative pleural adhesions by regulating local inflammation. This multifunctional hydrogel platform provided an integrated cardiac repair solution in a minimally invasive manner, combining structural support, electrical integration, and biochemical regulation. 2026-09-29T00:00:00Z Dataset Media 10.1021/acsnano.6c10157.s001 https://figshare.com/articles/media/In_Situ_Photocurable_Janus_Hydrogels_with_Magnetically_Guided_Anisotropic_Conductivity_for_Myocardial_Ischemeia_Reperfusion_Injury_Treatment_and_Tissue_Adhesion_Prevention/34021782 CC BY-NC 4.0