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oai:figshare.com:article/34021731 2026-09-29T07:04:09Z category_4 category_7 category_8 category_12 category_13 category_14 category_21 category_734 category_811 category_61 category_64 category_128 category_132 category_133 portal_63 item_type_6 month_year_09_2026

Multimatrix Biomonitoring and Transplacental Transfer of Legacy and Emerging PFAS in Korean Pregnant Women Hyewon Shin (7037438) Na-Youn Park (4798590) Young Ah Lee (7305380) Jong Kwan Jun (7309832) Kyungho Choi (513597) Sun Wook Cho (8911283) Younglim Kho (1928767) Biochemistry Medicine Microbiology Cell Biology Genetics Molecular Biology Biotechnology Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified Developmental Biology Cancer Hematology Infectious Diseases Plant Biology fetal growth indicators 2 dipap showed alternative pfas 9cl specific exposure profiles measured 33 legacy bound pfas detected regulated legacy pfas specific pfas detection consistently detected emerging pfas transplacental transfer pregnancy rather population level polyfluoroalkyl substances physicochemical properties neonatal factors n </ multimatrix biomonitoring findings suggest elimination pathways distribution patterns cord serum blood matrices Maternal–fetal exposure to per- and polyfluoroalkyl substances (PFAS) cannot be adequately characterized using single biological matrices because compound-specific distribution patterns vary according to physicochemical properties and elimination pathways. We measured 33 legacy, precursor, and emerging PFAS in maternal serum, plasma, urine, and cord serum from Korean singleton pregnancies (<i>n</i> = 151) to characterize matrix-specific exposure profiles, transplacental transfer, and associations with maternal and neonatal factors. Matrix-specific detection patterns distinguished predominantly protein-bound PFAS detected in blood matrices from short-chain, renally excreted PFAS prevalent in urine at the population level. Notably, the precursor 6:2 diPAP showed a relatively high estimated maternal–cord concentration ratio, whereas the alternative PFAS 9Cl-PF3ONS was consistently detected in maternal blood and cord serum, suggesting compound-specific distribution patterns compared with regulated legacy PFAS. Associations with fetal growth indicators were modest, matrix- and sex-specific, and interpreted as exploratory. Overall, these findings suggest that multimatrix biomonitoring can reveal matrix-specific PFAS detection and distribution patterns that may not be captured by single-matrix approaches. However, maternal–cord comparisons should be interpreted cautiously because maternal samples were collected during pregnancy rather than at delivery. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.est.6c08434.s001 https://figshare.com/articles/journal_contribution/Multimatrix_Biomonitoring_and_Transplacental_Transfer_of_Legacy_and_Emerging_PFAS_in_Korean_Pregnant_Women/34021731 CC BY-NC 4.0