2026-10-07T19:10:33Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34021491 2026-09-29T05:47:58Z category_140 portal_316 item_type_1 month_year_09_2026

Image 2_Serum free eicosapentaenoic acid-to-arachidonic acid ratio and long-term risk of major adverse cardiovascular events in patients with coronary artery disease.tiff Changguo Ou (25135554) Wenli Wang (1701169) Dongliang Liang (9116744) Jiangxiong Wen (8783708) Zhiwen Xu (28724) Yuli Huang (491990) Jianqiu Liang (25135557) Jiandi Wu (11900273) Cardiology coronary artery disease free EPA/AA ratio major adverse cardiovascular events non-esterified fatty acids prognosis Background<p>The eicosapentaenoic acid to arachidonic acid (EPA/AA) ratio reflects the balance between n-3 and n-6 polyunsaturated fatty acids. We examined the association between the serum free (non-esterified) EPA/AA ratio and long-term major adverse cardiovascular events (MACE) in patients with angiographically confirmed coronary artery disease (CAD).</p>Methods<p>This single-center retrospective cohort study included 308 patients with CAD. Serum free fatty acids were quantified by LC-MS/MS, and the free EPA/AA ratio was evaluated as the primary fatty-acid biomarker. Cox proportional hazards models were used to estimate hazard ratios (HRs), and principal component analysis (PCA) was used to explore fatty-acid patterns.</p>Results<p>During a median follow-up of 48.7 months, 201 first MACE events occurred. In the fully adjusted primary analysis, each 1-SD increase in the free EPA/AA ratio was associated with a lower risk of MACE (HR = 0.82, 95% CI 0.70–0.96, P = 0.011; FDR-adjusted P = 0.049). The association was attenuated after additional adjustment for analytical batch (HR = 0.92, 95% CI 0.77–1.10, P = 0.375) and in a Cox model stratified by batch (HR = 0.92, 95% CI 0.77–1.11, P = 0.398).</p>Conclusions<p>A higher serum free EPA/AA ratio was associated with a lower risk of MACE in the primary multivariable analysis, but the association was attenuated in additional sensitivity analyses. These findings should be interpreted cautiously and require validation in independent cohorts.</p> 2026-09-29T05:47:58Z Image Figure 10.3389/fcvm.2026.1944383.s003 https://figshare.com/articles/figure/Image_2_Serum_free_eicosapentaenoic_acid-to-arachidonic_acid_ratio_and_long-term_risk_of_major_adverse_cardiovascular_events_in_patients_with_coronary_artery_disease_tiff/34021491 CC BY 4.0