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oai:figshare.com:article/34021353 2026-09-29T05:26:21Z category_393 portal_316 item_type_3 month_year_09_2026

Supplementary file 1_Pediatric lymphomatoid papulosis: a broad clinicopathologic spectrum including rare variants in a single-center case series.docx Margherita Pelucchi (25135398) Andrea Michelerio (25135401) Elif Tamay Gul (25135404) Alessandro Svizzero (25135407) Elisa Curto (25135410) Giuseppe Neri (14167326) Marco Paulli (2592475) Valeria Brazzelli (19822692) Foetal Development and Medicine lymphomatoid papulosis pediatric patients; cutaneous CD30-positive lymphoproliferative disorders histopathology; immunohistochemistry T-cell lymphoma Background<p>Lymphomatoid papulosis (LyP) is a rare CD30-positive cutaneous T-cell lymphoproliferative disorder, extremely uncommon in children and adolescents. Despite its indolent course, LyP may mimic malignant lymphomas clinically and histopathologically, making diagnosis challenging in pediatric patients.</p>Objectives<p>To characterize the clinical, histopathologic, immunophenotypic and molecular features of pediatric LyP and to describe treatment approaches and clinical outcomes.</p>Methods<p>We performed a retrospective observational study of pediatric patients with clinicopathologically confirmed LyP evaluated at our tertiary referral center between 2004 and 2025. Demographic, clinical, histopathologic, immunophenotypic, molecular, treatment and follow-up data were collected.</p>Results<p>Nine patients were included (8 males, 1 female), with a median age at diagnosis of 11 years (range 2–18). Lesions predominantly involved the limbs (9/9, 100%), followed by the trunk (5/9, 56%) and hands (4/9, 44%). Ulceration or necrotic evolution occurred in 6/9 patients (67%). Type A was the most common histologic subtype (5/9, 56%), followed by single cases of types B, D, E and one overlap A–C case. CD30 expression was observed in all patients. T-cell receptor clonality was identified in 4/5 tested cases. Management was mainly conservative, consisting of topical corticosteroids and phototherapy (nbUVB or PUVA). Methotrexate was used in one patient. At the last follow-up, all patients were free of active LyP lesions, and no associated hematologic malignancy was documented.</p>Conclusions<p>Pediatric LyP shows heterogeneous clinicopathologic features with overall favorable outcomes. However, long-term follow-up remains warranted due to the lifelong risk of associated lymphoproliferative disorders.</p> 2026-09-29T05:26:21Z Dataset Dataset 10.3389/fmed.2026.1948975.s001 https://figshare.com/articles/dataset/Supplementary_file_1_Pediatric_lymphomatoid_papulosis_a_broad_clinicopathologic_spectrum_including_rare_variants_in_a_single-center_case_series_docx/34021353 CC BY 4.0