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oai:figshare.com:article/34021304 2026-09-29T05:04:34Z category_4 category_13 category_24 category_272 category_873 category_39 category_135 portal_63 item_type_6 month_year_09_2026

MgAlO^tBu Catalyzed Synthesis of Oxaziridines Autumn J. Vossler (25135313) Chrishene R. B. Mapitigama (25135316) Prinsee R. Patel (25135319) Nicholas J. Lahr (25135322) DaEisha N. Robinson (25135325) Rashanique D. Quarels (5687183) Biochemistry Genetics Evolutionary Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Ecology Computational Biology sup >< italic environmentally conscious approach sustainable oxidation protocol recyclable heterogeneous catalyst described using hydrotalcite bu catalyzed synthesis hydrotalcite catalyst imine oxidation transformation delivers transfer chemistry readily recovered oxaziridine synthesis minimal loss mild heating method optimization hydrogen peroxide green oxidant green nitrogen features establish chlorinated oxidants 90 %. A sustainable oxidation protocol for the synthesis of oxaziridines from aldimines is described using hydrotalcite as a recyclable heterogeneous catalyst and hydrogen peroxide as a green oxidant. This operationally simple method proceeds under mild heating and avoids the need for chlorinated oxidants or metal-based reagents traditionally employed for imine oxidation. Across 25 representative substrates, including both aromatic and aliphatic aldimines, the transformation delivers the corresponding oxaziridines in yields up to 90%. The hydrotalcite catalyst can be readily recovered by filtration and reused with minimal loss of activity. Together, these features establish a practical, scalable, and environmentally conscious approach to oxaziridine synthesis that expands the toolbox of green nitrogen-transfer chemistry. Method optimization, scope, and limitations are discussed. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acsomega.6c07428.s001 https://figshare.com/articles/journal_contribution/MgAlO_sup_t_sup_Bu_Catalyzed_Synthesis_of_Oxaziridines/34021304 CC BY-NC 4.0