2026-10-14T12:54:59Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34021100 2026-09-29T04:10:46Z category_1 category_4 category_7 category_8 category_14 category_45 portal_63 item_type_6 month_year_09_2026

Total Synthesis of Complex Nucleoside Antibiotics Ezomycin A1 and A2 Zhoupeng Zhao (25135094) Shuai Fan (5158127) Shuaibo Yang (11655357) Xianglong Xie (25135097) Shixiong Chen (8068010) Xiaolei Wang (139592) Biophysics Biochemistry Medicine Microbiology Molecular Biology Sociology unified synthetic route polar functional groups formidable synthetic challenges catalyzed reductive cross de novo </ asymmetric carbohydrate synthesis 2 </ sub trans </ total synthesis p </ n </ sterically demanding stereoselective nickel precise assembly modular strategy mild (< ezomycin family century due >- glycosylation The complex nucleoside antibiotics ezomycin A1 and A2 have stood as formidable synthetic challenges for half a century due to their density of polar functional groups and unique <i>trans</i>-fused bicyclic framework. Here, we disclose their long-awaited first total synthesis. This convergent and modular strategy is enabled by a stereoselective nickel-catalyzed reductive cross-coupling, a <i>de novo</i> asymmetric carbohydrate synthesis, and a mild (<i>p</i>-Tol)₂SO/Tf₂O-promoted <i>N</i>-glycosylation. This work not only establishes a unified synthetic route to the ezomycin family but also provides robust methodologies for the precise assembly of sterically demanding, highly functionalized nucleoside natural products. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/jacs.6c14230.s001 https://figshare.com/articles/journal_contribution/Total_Synthesis_of_Complex_Nucleoside_Antibiotics_Ezomycin_A1_and_A2/34021100 CC BY-NC 4.0