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oai:figshare.com:article/34021069 2026-09-29T04:03:58Z category_1 category_4 category_7 category_8 category_21 category_873 category_45 category_132 category_134 category_135 portal_63 item_type_6 month_year_09_2026

A Phosphotungstate Catalyst with Both Brønsted and Lewis Acid Sites for Synthesis of Bis(indolyl)methane Derivatives Miao Zhang (17216) Lin Chen (54305) Chizhao Song (24455302) Bing Yan (170259) Lin Sun (105539) Qiuxia Han (1791697) Pengtao Ma (779212) Biophysics Biochemistry Medicine Microbiology Biotechnology Chemical Sciences not elsewhere classified Sociology Infectious Diseases Virology Computational Biology reaction proceeds efficiently possible catalytic mechanism new catalytic strategies lewis acid sites electrophilic substitution reaction attracted increasing attention phosphotungstate [( ch room temperature without 9 </ sub 2 </ sub room temperature yielding reactions thereby expanding synthetic scope synthesized via short period phosphotungstate catalyst methane derivatives key method expanding applications diarylmethane derivatives completed within based compounds also proposed (< b The Friedel–Crafts alkylation of indoles with aldehydes is a key method for synthesizing bis(indolyl)methanes (BIMs). With the expanding applications of BIMs in medicine and agriculture, the development of new catalytic strategies to facilitate their synthesis has attracted increasing attention. In this study, we report a mild, cost-effective, and environmentally friendly catalyzed Friedel–Crafts reaction of indoles with aldehydes. The catalyst, phosphotungstate [(CH₃)₂NH₂]₉[Sb₃(A-α-PW₉O₃₄)₂]·7H₂O (<b>SbPW</b>), was synthesized via a conventional aqueous solution method. The reaction proceeds efficiently at room temperature under solvent-free conditions. Under these conditions, high-yielding reactions were achieved for the synthesis of diarylmethane derivatives from a variety of aliphatic and aromatic aldehydes, thereby expanding the synthetic scope of indole-based compounds. The electrophilic substitution reaction was completed within a short period at room temperature without the need for a solvent, and a possible catalytic mechanism is also proposed. 2026-09-29T00:00:00Z Text Journal contribution 10.1021/acs.inorgchem.6c02847.s001 https://figshare.com/articles/journal_contribution/A_Phosphotungstate_Catalyst_with_Both_Br_nsted_and_Lewis_Acid_Sites_for_Synthesis_of_Bis_indolyl_methane_Derivatives/34021069 CC BY-NC 4.0