2026-10-13T14:50:44Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34021065 2026-09-29T04:24:25Z category_31208 category_31226 category_31211 portal_1005 item_type_6 month_year_09_2026

Paving the Way: a Systematic Review and Meta-Analysis of Randomized Controlled Trials of Atherectomy as Vessel Preparation Prior to Balloon Angioplasty in Peripheral Arterial Disease JQJ Ho (25135065) S Udayasiri (25135068) M Stewart (2898173) A Owen (7812983) N Kutaiba (13437894) J Low (12516163) A Khabaza (15189403) D Ranatunga (13387113) Julian Maingard (13082895) M Brooks (9863258) A Jhamb (13323327) L Corlette (25135071) C Handley (9858392) C Barras (13397745) HK Kok (14446083) Hamed Asadi (13059153) Biomedical and clinical sciences Clinical sciences Cardiovascular medicine and haematology Science & Technology Life Sciences & Biomedicine Cardiac & Cardiovascular Systems Radiology, Nuclear Medicine & Medical Imaging Cardiovascular System & Cardiology Peripheral arterial disease Atherectomy Balloon angioplasty Vessel preparation Drug-coated balloon Clinical Research Cardiovascular Clinical Trials and Supportive Activities Atherosclerosis 6.1 Pharmaceuticals 3 Good Health and Well Being Humans Peripheral Arterial Disease Randomized Controlled Trials as Topic Angioplasty, Balloon Treatment Outcome Vascular Patency Purpose: This systematic review and meta-analysis compares the safety and efficacy of atherectomy as a vessel preparation tool prior to balloon angioplasty (ATH + BA) versus balloon angioplasty alone (BA) for the treatment of peripheral arterial disease (PAD). Materials and Methods: Medline, Embase, CENTRAL, and Clinicaltrials.gov databases were searched for randomized controlled trials (RCTs) comparing ATH + BA versus BA alone in treating PAD. The outcomes analysed included primary patency, technical success, bailout stenting, flow-limiting dissection, clinically driven target lesion revascularization (CD-TLR), distal embolization, arterial perforation, major amputation, and all-cause mortality. A subgroup analysis was done to compare femoropopliteal versus infrapopliteal and plain balloon angioplasty versus drug-coated balloon. Results: Seven RCTs met the inclusion criteria (489 patients). Atherectomy as vessel preparation was associated with reduced rates of bailout stenting (OR: 0.14, 95% CI 0.03–0.67, p = 0.01) and flow-limiting dissection (OR: 0.29, 95% CI 0.10–0.84, p = 0.02). Primary patency (OR: 2.13, 95% CI 1.00–4.50, p = 0.049) and CD-TLR at 6 months (OR: 0.24, 95% CI 0.06–0.96, p = 0.04) results favoured ATH + BA. No significant differences were found in technical success, 12-month primary patency, CD-TLR at 12 months, distal embolization, arterial perforation, major amputation, or all-cause mortality. Subgroup analysis demonstrated a reduction in bailout stenting in femoropopliteal studies (OR: 0.05, 95% CI 0.01–0.21) compared with infrapopliteal studies (OR: 0.86, 95% CI 0.31–2.40). Conclusions: This meta-analysis found that atherectomy as vessel preparation prior to BA reduced bailout stenting, flow-limiting dissections, and 6-month CD-TLR, with improved 6-month patency compared with BA alone. However, these benefits did not translate into improvements in clinical outcomes at 12 months. Larger RCTs are needed to establish the clinical benefit of atherectomy. 2026-01-01T00:00:00Z Text Journal contribution 10.26187/deakin.34021065 https://figshare.com/articles/journal_contribution/Paving_the_Way_a_Systematic_Review_and_Meta-Analysis_of_Randomized_Controlled_Trials_of_Atherectomy_as_Vessel_Preparation_Prior_to_Balloon_Angioplasty_in_Peripheral_Arterial_Disease/34021065 CC BY 4.0