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oai:figshare.com:article/34018841 2026-09-29T01:03:52Z category_1 category_4 category_14 category_734 category_61 portal_63 item_type_6 month_year_09_2026

Rongalite-Promoted One-Pot Reductive Cyclization Strategy for the Construction of Pyrrolo[1,2-α]quinoxalines from 1‑(2-Nitrophenyl)pyrroles Shivaji V. Surve (25133618) Pandurang B. Hardas (25133621) Umesh A. Kshirsagar (1944721) Biophysics Biochemistry Molecular Biology Biological Sciences not elsewhere classified Developmental Biology several control experiments formaldehyde detection experiments nitrophenyl )- 1 1 ‑( 2 1 -( 2 reduction studies reducing agent readily scalable reaction mechanism h </ free strategy dual function alternative approach >- pyrrole A transition-metal-free strategy for the synthesis of pyrrolo[1,2-α]quinoxalines and 7-methylindolo[1,2-α]quinoxaline from 1-(2-nitrophenyl)-1<i>H</i>-pyrrole or 3-methyl-1-(2-nitrophenyl)-1<i>H</i>-indole using rongalite have been developed. In this transformation, rongalite serves a dual function, acting as both a reducing agent and a one-carbon (C1) synthon. The method offers an alternative approach to C–N bond formation. Furthermore, to investigate the reaction mechanism, several control experiments were performed, including radical scavenger studies, formaldehyde detection experiments, and reduction studies. The method is readily scalable and enables further modification. 2026-09-28T00:00:00Z Text Journal contribution 10.1021/acs.joc.6c01671.s001 https://figshare.com/articles/journal_contribution/Rongalite-Promoted_One-Pot_Reductive_Cyclization_Strategy_for_the_Construction_of_Pyrrolo_1_2-_quinoxalines_from_1_2-Nitrophenyl_pyrroles/34018841 CC BY-NC 4.0