2026-10-14T05:34:25Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018838 2026-09-29T01:03:21Z category_4 category_7 category_8 category_12 category_13 category_16 category_19 category_873 category_39 category_135 portal_63 item_type_6 month_year_09_2026

Oligosaccharides from Dendrobium officinale Ameliorate Metabolic Dysfunction in db/db Mice by Modulating Gut Microbiota, Short-Chain Fatty Acid Production, and Intestinal Barrier Integrity Yuan Li (67017) Tong Gao (341025) Ziying Wang (1305600) Mengyuan Wang (4346869) Xiao Liang (185891) Wenxin Gao (10322366) Xiaodan Zhang (569294) Mengni Li (3807346) Zongsuo Liang (185893) Biochemistry Medicine Microbiology Cell Biology Genetics Physiology Pharmacology Chemical Sciences not elsewhere classified Ecology Computational Biology intestinal barrier function chain fatty acids lipid metabolic disorders t2dm remain unclear reduced intestinal permeability modulating gut microbiota gut microbiota composition related metabolic disorders db </ italic gut microbiota metabolic parameters regulated gut t2dm ). related neuropeptides reduced pancreatic muc2 </ db </ study evaluated lps ), inflammatory markers increased expression increased abundances host metabolism hepatic injury findings suggest dietary interventions derived hormones dendrobium officinale attracted attention >, zo Functional oligosaccharides have attracted attention as dietary interventions for type 2 diabetes mellitus (T2DM). However, the effects of oligosaccharides derived from Dendrobium officinale (DOO1) in T2DM remain unclear. This study evaluated the effects of DOO1 on metabolic parameters, gut microbiota, short-chain fatty acids (SCFAs) production, intestinal barrier function, and host metabolism in <i>db/db</i> mice. DOO1 significantly improved glucose and lipid metabolic disorders and reduced pancreatic and hepatic injury. These effects were accompanied by changes in gut microbiota composition, characterized by increased abundances of Duncaniella, Muribaculum, and Paramuribaculum, along with elevated fecal SCFA levels. DOO1 improved intestinal barrier function, as indicated by reduced intestinal permeability and inflammatory markers (TNF-α, IL-1β, LPS), and increased expression of <i>Muc2</i>, ZO-1, and Claudin-1. DOO1 also altered host metabolic profiles and regulated gut-derived hormones and appetite-related neuropeptides. Overall, these findings suggest that DOO1 may alleviate T2DM-related metabolic disorders by modulating gut microbiota and host metabolism. 2026-09-28T00:00:00Z Text Journal contribution 10.1021/acs.jafc.6c08217.s001 https://figshare.com/articles/journal_contribution/Oligosaccharides_from_Dendrobium_officinale_Ameliorate_Metabolic_Dysfunction_in_db_db_Mice_by_Modulating_Gut_Microbiota_Short-Chain_Fatty_Acid_Production_and_Intestinal_Barrier_Integrity/34018838 CC BY-NC 4.0