2026-10-11T21:29:06Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018583 2026-09-28T22:04:15Z category_1 category_13 category_14 category_272 category_873 category_734 category_811 portal_63 item_type_6 month_year_09_2026

A “Claw-Capture” Multiplex Electrochemical Sensing Platform for Ultrasensitive and Hierarchical Detection of Hg(II) Based on Nanochannel-Confined Hollow Ce(III)-MOF Nanofibers Coupled with l‑Cysteine Yuan Feng (213823) Yuxiu Liu (106255) Guo Yu (57644) Ximing Guo (66272) Biophysics Genetics Molecular Biology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Mathematical Sciences not elsewhere classified strong recognition performance strong covalent bond strong coordination effect signal amplification tag exhibit excellent anti complex serum samples capture ″ strategy cv ), square confined hollow ce iii )/ ce cys toward hg ″ claw swv ), “ low “ claw wave voltammetry successfully designed spontaneous cycling spatial repulsion first time fast method environmental wastewater effectively improve dose accumulation cys ), cyclic voltammetry biotoxicity characteristics antifouling properties accuracy requirements Herein, according to the biotoxicity characteristics of Hg(II) with “low-dose accumulation and high-dose acute injury,” we successfully designed for the first time a multiplex electrochemical sensing platform based on the ″claw-capture″ strategy for staged detection of Hg(II). The multiplex electrochemical sensing platform was fabricated based on nanochannel-confined hollow Ce(III)-MOF nanofibers coupled with l-cysteine (l-Cys), which can detect Hg(II) in environmental wastewater and complex serum samples with high sensitivity and a large-span concentration. The uniformly ordered microporous hollow Ce(III)-MOF nanofibers not only exhibit excellent anti-interference and antifouling properties through electrostatic and spatial repulsion, but also the spontaneous cycling of Ce(III)/Ce(IV) based on the strong coordination effect between l-Cys and Ce(III) and the strong covalent bond between l-Cys and Hg(II), which serves as a signal amplification tag in a multiplex electrochemical sensing platform. The strong recognition performance of l-Cys toward Hg(II) can further effectively improve the sensitivity and selectivity to distinguish potential destructive metal species. In addition, this electrochemical sensing platform selects corresponding testing methods from cyclic voltammetry (CV), square-wave voltammetry (SWV), and chronoamperometry (CA) based on the concentration range and accuracy requirements of Hg(II) detection. Therefore, the novel electrochemical sensing platform provides a convenient and fast method for precise detection of Hg(II) in complex serum samples and environmental wastewater, as well as for staged detection of Hg(II) concentration by selecting matching electrochemical testing methods. 2026-09-28T00:00:00Z Text Journal contribution 10.1021/acs.langmuir.6c04983.s001 https://figshare.com/articles/journal_contribution/A_Claw-Capture_Multiplex_Electrochemical_Sensing_Platform_for_Ultrasensitive_and_Hierarchical_Detection_of_Hg_II_Based_on_Nanochannel-Confined_Hollow_Ce_III_-MOF_Nanofibers_Coupled_with_l_Cysteine/34018583 CC BY-NC 4.0