2026-10-14T13:01:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018414 2026-09-28T20:13:27Z category_4 category_21 category_272 category_873 category_132 portal_63 item_type_6 month_year_09_2026

Biomimetic Fe(Pytacn)-Catalyzed Intramolecular C(sp³)–H Amination: Access to Heteroarene-Functionalized Sultams Xu Liu (276996) Ming-Hao Zhao (25133230) Yuchen Yang (21709) Lijia Wang (314011) Biochemistry Biotechnology Environmental Sciences not elsewhere classified Chemical Sciences not elsewhere classified Infectious Diseases mechanistic studies demonstrate temperature conditions radical pathway pytacn ligand protocol operates new fe mild room functionalized sultams easily modified bulky substituents biomimetic fe acac counterion 1 dr A new Fe(Pytacn)-catalyzed intramolecular aliphatic C(sp³)–H amination system is reported for the first time via metal-nitrene-mediated C–H insertion. This protocol operates under mild room-temperature conditions, affording 20 structurally diverse sultams in up to 90% yield with up to >20:1 dr, including synthetically challenging substrates bearing heteroatoms or bulky substituents. Mechanistic studies demonstrate a radical pathway, with both Pytacn ligand and acac counterion being critical; the kinetic isotopic effect indicates C–H insertion is rate-determining. The products can be easily modified with various building blocks via simple chemical transformations. 2026-09-28T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03825.s001 https://figshare.com/articles/journal_contribution/Biomimetic_Fe_Pytacn_-Catalyzed_Intramolecular_C_sp_sup_3_sup_H_Amination_Access_to_Heteroarene-Functionalized_Sultams/34018414 CC BY-NC 4.0