2026-10-12T10:09:46Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018340 2026-09-28T20:00:06Z category_4 category_8 category_16 category_21 category_272 category_46 category_734 category_64 portal_87 item_type_3 month_year_09_2026

Piceatannol enzymatically derived from resveratrol protects against UVB-induced skin injury by modulating antioxidant and inflammatory pathways Muhammad Umar (604981) Muhammad Aamir Zohaib (25133171) Penghao Gao (18928715) Muhammad Haseeb Akhlaq (25133174) Liping Dong (255033) Jiahui Xia (165609) Duxin Li (13791358) Jianqin Zhou (70435) Biochemistry Microbiology Physiology Biotechnology Environmental Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Cancer Piceatannol tyrosinase resveratrol UVB-induced skin damage antioxidant anti-inflammatory <p>This study focused on optimising the tyrosinase-catalysed conversion of resveratrol (RES) to piceatannol (PCT) for efficient, low-cost production, as well as investigating the protective effects of PCT against UVB-induced skin damage. Conditions were optimised by adjusting temperature, enzyme concentration, pH, Vitamin C concentration, and reaction time. In HaCaT cell experiments, PCT provided greater cytoprotection than RES by improving cell survival, lowering UVB-induced ROS accumulation, increasing the activities of key antioxidant enzymes, and suppressing inflammatory mediators more effectively. Consistently, <i>in vivo</i> mice experiment confirmed that PCT alleviated UVB-induced erythema and histological damage more effectively than RES, while better supporting collagen remodelling and epidermal repair. Overall, PCT exhibited superior antioxidant, anti-inflammatory, and skin-repair activities supporting its potential value as a natural active ingredient for photoprotection and skin repair.</p> 2026-09-28T20:00:06Z Dataset Dataset 10.6084/m9.figshare.34018340.v1 https://figshare.com/articles/dataset/Piceatannol_enzymatically_derived_from_resveratrol_protects_against_UVB-induced_skin_injury_by_modulating_antioxidant_and_inflammatory_pathways/34018340 CC BY 4.0