2026-10-13T12:35:04Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018278 2026-09-28T19:07:16Z category_1 category_4 category_21 category_873 category_46 category_734 category_61 category_132 portal_63 item_type_6 month_year_09_2026

A ROS-Responsive Pectin/PVA Hydrogel Loaded with Ganoderma atrum Polysaccharide Accelerates Diabetic Wound Healing by Polarizing Macrophages toward the M2 Phenotype Leyi Wei (3959444) Fansen Zeng (11560979) Quan Li (157017) Yufei Yao (11504272) Mengqiao Li (3594575) Wenjuan Li (308527) Biophysics Biochemistry Biotechnology Chemical Sciences not elsewhere classified Immunology Biological Sciences not elsewhere classified Developmental Biology Infectious Diseases skin appendage regeneration showed excellent biocompatibility polarizing macrophages toward macrophage inflammatory responses ganoderma atrum </ enhanced collagen deposition diabetic wound model multifunctional hydrogel based psg hydrogel provides suppressed ros accumulation pva hydrogel loaded responsive hydrogel vinyl alcohol upregulated pd responsive pectin phenylboronic acid natural polymer m2 phenotype innovative strategy healing ability functionalized pectin elevated il dysregulated inflammation day 14 achieving 93 Diabetic chronic wound healing is hindered by excessive reactive oxygen species (ROS) and dysregulated inflammation. To address this challenge, we developed a multifunctional hydrogel based on natural polymer. Specifically, an ROS-responsive hydrogel was fabricated via dynamic boronate ester bonds between phenylboronic acid-functionalized pectin (Pe-PBA) and poly(vinyl alcohol) (PVA), then loaded with <i>Ganoderma atrum</i> polysaccharide (PSG), termed Pe/PVA@PSG. The obtained hydrogel exhibited excellent mechanical properties and self-healing ability, enabling efficient PSG release triggered in response to high-glucose and -ROS conditions. In vitro, it showed excellent biocompatibility, significantly facilitated fibroblast proliferation and migration, and suppressed ROS accumulation and macrophage inflammatory responses. In a diabetic wound model, Pe/PVA@PSG markedly accelerated wound closure, achieving 93.42% closure on day 14, which enhanced collagen deposition and skin appendage regeneration, elevated IL-10, upregulated PD-L1, and drove macrophage polarization toward the M2 phenotype. Overall, the Pe/PVA@PSG hydrogel provides an innovative strategy for chronic diabetic wound management. 2026-09-28T00:00:00Z Text Journal contribution 10.1021/acs.jafc.6c09422.s001 https://figshare.com/articles/journal_contribution/A_ROS-Responsive_Pectin_PVA_Hydrogel_Loaded_with_Ganoderma_atrum_Polysaccharide_Accelerates_Diabetic_Wound_Healing_by_Polarizing_Macrophages_toward_the_M2_Phenotype/34018278 CC BY-NC 4.0