2026-10-11T09:10:57Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018245 2026-09-28T19:04:16Z category_14 category_21 category_873 category_734 category_135 portal_63 item_type_6 month_year_09_2026

Transfer Hydrogenation of Nitrones to Hydroxylamine Derivatives with PhSiH₃ Wanzhen Guo (25133091) Xin Liu (43569) Xing Lu (1438414) Zhiqiang Ren (294429) Yuqi Zhang (286958) Bo Han (84102) Molecular Biology Biotechnology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Computational Biology corresponding hydroxylamine derivatives 3 </ sub readily available phsih hydroxylamine derivatives readily scalable wide range transfer hydrogenation sustainable strategy mild conditions hydrogen donor furan substituents free method findings demonstrated excellent yields effective conversion accommodating bromo Herein, we report a practical metal- and additive-free method for transfer hydrogenation of nitrones, employing a readily available PhSiH₃ as the hydrogen donor. The findings demonstrated the effective conversion of a wide range of ketone- and aldehyde-derived nitrones into their corresponding hydroxylamine derivatives in good to excellent yields under mild conditions. The reaction is readily scalable and demonstrates broad functional group tolerance, accommodating bromo, chloro, fluoro, trifluoromethyl, thioether, thiophene, and furan substituents. Hence, the proposed operationally simple protocol provides a practical and sustainable strategy, facilitating the synthesis of structurally diverse hydroxylamine derivatives. 2026-09-28T00:00:00Z Text Journal contribution 10.1021/acs.orglett.6c03328.s001 https://figshare.com/articles/journal_contribution/Transfer_Hydrogenation_of_Nitrones_to_Hydroxylamine_Derivatives_with_PhSiH_sub_3_sub_/34018245 CC BY-NC 4.0