2026-10-14T04:55:15Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018224 2026-09-30T20:30:48Z category_30881 category_31034 category_30992 portal_1044 item_type_3 month_year_09_2026

Data and code associated with: Deconstruction of Saccharomyces hybrids reveals multiple genomic regions required for thermotolerance Justin Fay (22277095) Nilima Walunjkar (25133060) James Miller (25133062) Biological sciences Genetics Evolutionary biology Saccharomyces thermotolerance thermal adaptation interspecific hybrids evolutionary genetics MMS21 <p dir="ltr">How new traits evolve and give rise to differences between species is a central question in biology. Although many studies have identified genes that contribute to variation within species, much less is known about the genetic changes responsible for differences that accumulate between species over millions of years. One challenge is that species often become reproductively isolated, making it difficult to map and identify genes that contribute to evolved traits.</p><p dir="ltr">In this study, we used hybrids between different yeast species to investigate the evolution of thermotolerance, the ability to grow at high temperatures. By selectively removing chromosomes inherited from one species in the hybrid, we found that thermotolerance depends on many regions distributed across the genome. Focusing on one chromosome, we identified a gene called <i>MMS21</i> that contributes to growth at elevated temperatures, while also showing that additional regions on the same chromosome are required for thermotolerance.</p><p dir="ltr">Our results suggest that thermotolerance evolved through the accumulation of many genetic changes, each playing an important role in enabling growth at high temperatures. More broadly, our work demonstrates how hybrid genetic approaches can overcome barriers between species and provide insight into the genetic basis of traits that have evolved over long periods of evolutionary time.</p> 2026-09-30T20:30:48Z Dataset Dataset 10.60593/ur.d.34018224.v1 https://figshare.com/articles/dataset/Data_and_code_associated_with_Deconstruction_of_Saccharomyces_hybrids_reveals_multiple_genomic_regions_required_for_thermotolerance/34018224 CC BY 4.0