2026-10-13T06:57:03Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34018128 2026-09-28T18:05:19Z category_1 category_4 category_13 category_14 category_21 category_24 category_873 category_734 category_931 category_64 category_132 category_135 portal_63 item_type_3 month_year_09_2026

Preparation of Bicyclopyrazolium Scaffolds and Their Application toward 1,3-Difunctionalization Yufei Zhang (509147) Hammed O. Bisiriyu (25132935) Patricia Z. Musacchio (14241135) Biophysics Biochemistry Genetics Molecular Biology Biotechnology Evolutionary Biology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Information Systems not elsewhere classified Cancer Infectious Diseases Computational Biology application toward 1 various nucleophiles undergoes cyclization synthesizing 2 strategy employs pyrazolium structure photocatalyzed method phenylpropyl halides pendant halide ium compounds bicyclopyrazolium scaffolds >] pyrazol >- pyrazolo >- benzylpyrazole 2 -< A photocatalyzed method for synthesizing 2,3-dihydro-1<i>H</i>-pyrazolo[1,2-<i>a</i>]pyrazol-4-ium compounds from pyrazole and 3-phenylpropyl halides is reported. The strategy employs a formal hydride abstraction process achieved through a stepwise hydrogen atom transfer and oxidative radical–polar crossover process to generate a benzylic carbocation. Capture of the carbocation with pyrazole generates an intermediate <i>N</i>-benzylpyrazole, which undergoes cyclization with a pendant halide to form a fused bicyclic pyrazolium scaffold. We demonstrate that the pyrazolium structure can serve as an intermediate toward accomplishing 1,3-difunctionalization through further reaction with various nucleophiles. 2026-09-28T00:00:00Z Dataset Dataset 10.1021/acsorginorgau.6c00069.s001 https://figshare.com/articles/dataset/Preparation_of_Bicyclopyrazolium_Scaffolds_and_Their_Application_toward_1_3-Difunctionalization/34018128 CC BY-NC 4.0