2026-10-13T03:01:29Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34017965 2026-09-28T17:58:33Z category_1 category_4 category_915 category_12 category_14 category_16 category_21 category_46 category_734 category_61 category_69 category_133 portal_5 item_type_1 month_year_09_2026

<p>Model for organisation of ɑ-actinin-2, ZASP and titin Z1Z2 domains in the Z-disc (cardiac myofibrils).</p> Oliver Umney (20106066) Alistair P. Curd (25132880) Heather L. Martin (25132883) Tarek Lewis (25132886) Anna Ah-San Tang (25132889) Thembaninkosi Gaule (25132892) Iain W. Manfield (11978060) Harikrushnan Balasubramanian (25132895) Satya Khuon (263722) Jesse Aaron (197822) Michelle Peckham (3912823) Biophysics Biochemistry Physical Sciences not elsewhere classified Cell Biology Molecular Biology Physiology Biotechnology Immunology Biological Sciences not elsewhere classified Developmental Biology Inorganic Chemistry Plant Biology basic repeating unit div >< p similar repeating organisation determine protein organisation discs </ p cardiac muscle z 3 key proteins key role cardiac signalling 3 </ striated muscle used perpl underlying organisation relative positions pattern extraction located within joined together fluorescently labelled discs play analysis revealed analyse patterns 3d position <p><b>A:</b> Arrangement of actin, ɑ-actinin-2, ZASP and titin Z1Z2 in the axial view. The Z-disc in cardiac muscle contains 4-6 ɑ-actinin-2 repeats [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014309#pcbi.1014309.ref005" target="_blank">5</a>], and here 6 repeats are shown. The ɑ-actinin-2 molecules can also be organised into doublets of the homodimer, spaced 6 nm apart ([<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014309#pcbi.1014309.ref013" target="_blank">13</a>] not illustrated here for simplicity). <b>B:</b> Arrangement of actin, ɑ‑actinin‑2, ZASP and titin Z1Z2 in the transverse view (basketweave lattice). The lattice constants for titin Z1Z2 and parallel actin filaments are stable across the Z-disc, while the sets of anti-parallel actin filaments may move relative to one another. The rotation of the square lattice between different locations on the Z-disc is also shown [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1014309#pcbi.1014309.ref005" target="_blank">5</a>].</p> 2026-09-28T18:02:26Z Image Figure 10.1371/journal.pcbi.1014309.g003 https://figshare.com/articles/figure/_p_Model_for_organisation_of_-actinin-2_ZASP_and_titin_Z1Z2_domains_in_the_Z-disc_cardiac_myofibrils_p_/34017965 CC BY 4.0