2026-10-10T17:33:13Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34017731 2026-09-28T17:53:14Z category_1 category_4 category_915 category_7 category_12 category_13 category_14 category_16 category_873 category_734 category_61 category_128 category_135 portal_5 item_type_3 month_year_09_2026

<p>Differentially abundant proteins across nuclear cell-cycle comparisons.</p> Ana Paula Menezes (25132835) Camila Gachet-Castro (11579152) Suzanne McGill (11916067) Richard Burchmore (178746) Ariel Silber (25132838) Maria Carolina Elias (9906069) Júlia P. C. da Cunha (25132841) Biophysics Biochemistry Physical Sciences not elsewhere classified Medicine Cell Biology Genetics Molecular Biology Physiology Chemical Sciences not elsewhere classified Biological Sciences not elsewhere classified Developmental Biology Hematology Computational Biology unique cellular features transition using hydroxyurea regulating fundamental processes pyruvate kinase activities maintaining genomic integrity hu ), followed cd ), represents specific expression patterns previously underappreciated role gene expression regulation canonical regulatory mechanisms >, potentially influencing trypanosoma cruzi </ purified nuclear fraction metabolic enzymes including gene expression metabolic enzymes cruzi </ pivotal role variant histones valuable model temporal compartmentalization specialized organelles revealing distinct results suggest provide insights proteins involved proteins identified protein synthesis nucleoside metabolisms nuclear region nuclear proteome nuclear division microtubule dynamics increased levels immunofluorescence supported identified 2 eukaryotic models etiological agent dna replication diverging eukaryotes citrate synthase chromosome condensation <p>This workbook contains proteins with increased or decreased abundance in pairwise comparisons among G1/S, S, and G2/M nuclear fractions. Proteins upregulated (fold change (FC) >1.5 and False discovered rate (FDR) < 0.05) or downregulated (FC < 1.5, FDR < 0.05) in the G2/M versus G1/S, G1/S versus S, and S versus G2/M comparisons. For each protein, the table provides accession, description, abundance ratios, log2-transformed abundance ratios, p-values, adjusted p-values, and related quantitative metrics used to define differential abundance.</p> <p>(XLSX)</p> 2026-09-28T17:59:59Z Dataset Dataset 10.1371/journal.pntd.0013299.s012 https://figshare.com/articles/dataset/_p_Differentially_abundant_proteins_across_nuclear_cell-cycle_comparisons_p_/34017731 CC BY 4.0