2026-10-12T08:54:00Z
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2026-09-28T17:53:08Z
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<p>Summary of proteins canonically annotated to non-nuclear compartments detected in the <i>T. cruzi</i> nuclear proteome.</p>
Ana Paula Menezes (25132835)
Camila Gachet-Castro (11579152)
Suzanne McGill (11916067)
Richard Burchmore (178746)
Ariel Silber (25132838)
Maria Carolina Elias (9906069)
Júlia P. C. da Cunha (25132841)
Biophysics
Biochemistry
Physical Sciences not elsewhere classified
Medicine
Cell Biology
Genetics
Molecular Biology
Physiology
Chemical Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Hematology
Computational Biology
unique cellular features
transition using hydroxyurea
regulating fundamental processes
pyruvate kinase activities
maintaining genomic integrity
hu ), followed
cd ), represents
specific expression patterns
previously underappreciated role
gene expression regulation
canonical regulatory mechanisms
>, potentially influencing
trypanosoma cruzi </
purified nuclear fraction
metabolic enzymes including
gene expression
metabolic enzymes
cruzi </
pivotal role
variant histones
valuable model
temporal compartmentalization
specialized organelles
revealing distinct
results suggest
provide insights
proteins involved
proteins identified
protein synthesis
nucleoside metabolisms
nuclear region
nuclear proteome
nuclear division
microtubule dynamics
increased levels
immunofluorescence supported
identified 2
eukaryotic models
etiological agent
dna replication
diverging eukaryotes
citrate synthase
chromosome condensation
<p>Proteins identified in the nuclear proteome and annotated to non-nuclear compartments were grouped according to curated functional/subcellular categories based on annotation from TrypTag. Categories are not mutually exclusive. Only proteins identified in the present study are shown. The illustration was generated with the assistance of artificial intelligence (ChatGPT and manually edited by the authors for scientific accuracy.</p> <p>(TIF)</p>
2026-09-28T17:59:59Z
Image
Figure
10.1371/journal.pntd.0013299.s008
https://figshare.com/articles/figure/_p_Summary_of_proteins_canonically_annotated_to_non-nuclear_compartments_detected_in_the_i_T_cruzi_i_nuclear_proteome_p_/34017719
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