2026-10-13T16:05:42Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34017703 2026-09-28T17:53:02Z category_915 category_7 category_8 category_21 category_46 category_734 category_128 category_132 portal_5 item_type_1 month_year_09_2026

<p>Example of one protein (MSP5, PVP01_0418400) with extensive inter-individual variations in antibody binding among patients.</p> Rosita Asawa (25132843) Brittany Hazzard (14271698) Katie Ko (12809883) Kieran Tebben (14504872) John Tan (1865173) Tineke Cantaert (68002) Andrea Berry (6244949) Niraj Tolia (25132846) Jean Popovici (423629) David Serre (2815) Physical Sciences not elsewhere classified Medicine Microbiology Biotechnology Immunology Biological Sciences not elsewhere classified Hematology Infectious Diseases select vaccine candidates host immune system entire protein sequences develop new tools density peptide array analyses also revealed 5 billion people analyzed antibody responses many uncharacterized proteins plasmodium vivax </ clinical vivax malaria plasmodium </ vivax </ clinical importance antibody response wide perspective wide characterization unique pattern symptomatic individuals stage infections several nucleoporins naïve individuals malaria community infection worldwide important resource erythrocyte invasion data provide better detecting asymptomatic individuals antigens using <p>The x-axis represents the position of consecutive peptides assessed by the high-density array and the y-axis the fluorescence measured at each peptide. The yellow, orange and brown lines show the IgG antibody binding for three Cambodian patients, while the blue lines represent data from all malaria-naïve individuals (n = 10). The horizontal lines under the plot show locations where seven or more consecutive peptides have a signal greater than all malaria-naïve controls (colored by patient). The blue and orange boxes under each plot indicate annotated functional regions.</p> <p>(TIF)</p> 2026-09-28T17:53:52Z Image Figure 10.1371/journal.ppat.1014621.s003 https://figshare.com/articles/figure/_p_Example_of_one_protein_MSP5_PVP01_0418400_with_extensive_inter-individual_variations_in_antibody_binding_among_patients_p_/34017703 CC BY 4.0