2026-10-12T23:10:25Z
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oai:figshare.com:article/34017625
2026-09-28T17:52:32Z
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<p>Common genes expressed in early neuropil glia.</p>
Amanda A. G. Ferreira (25132828)
Sergio Córdoba (645937)
Raghuvanshi Rajesh (25132831)
Ben Jiwon Choi (25132834)
Claude Desplan (45436)
Cell Biology
Genetics
Neuroscience
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology
Plant Biology
innovative computational approach
genetic markers expressed
div >< p
subcellular mrna compartmentalization
optic lobe glia
two large single
detailed transcriptomic analysis
identify mrna species
glial diversity observed
adult visual system
glial cell bodies
glial cell types
understand glial development
visual system
cell mrna
cell bodies
glial types
glial cells
glia types
adult stages
cell class
cell atlas
neuropil glia
chiasm glia
work provides
transcriptionally appear
pupal stages
helps explain
gradually change
drosophila </
distinct mrnas
differentially localized
developmental trajectories
developmental single
comprehensively annotated
also present
allowed us
<p><b>(A–F)</b> UMAPs representing the integration of all glial cells from L3, P15, P30, P50, P70, and adult stages. Panels show the expression levels of genes that are common to the initial trajectory of neuropil glia lineages. Genes shown were the first six genes selected from <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3004015#pbio.3004015.s012" target="_blank">S4 Table</a> by highest avg_log2FC and pct.2 < 0.1 (cells from other clusters that expresses the same marker). Cells expressing the genes are shown on top of the other cells (order = T). <b>(G–I)</b> UMAPs showing only lobula neuropil glia integrated from all stages, displaying the expression levels of <i>CR30009</i>, <i>gcm</i> and <i>E(spl)malpha-BFM</i>. Cells expressing the genes are shown on top of the other cells (order = T). The proposed start for the lobula neuropil ALG (red arrow) and lobula neuropil EG (green arrow) glia are shown in each panel. Note the relative absence of early neuropil glia markers from the lobula neuropil ALG trajectory. The code used to generate the graphs can be found at <a href="https://zenodo.org/records/21890456" target="_blank">https://zenodo.org/records/21890456</a>.</p> <p>(TIFF)</p>
2026-09-28T17:57:37Z
Image
Figure
10.1371/journal.pbio.3004015.s004
https://figshare.com/articles/figure/_p_Common_genes_expressed_in_early_neuropil_glia_p_/34017625
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