2026-10-13T22:02:11Z
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oai:figshare.com:article/34017622
2026-09-28T17:52:31Z
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<p>Comparison of lamina and medulla glia lineages across development.</p>
Amanda A. G. Ferreira (25132828)
Sergio Córdoba (645937)
Raghuvanshi Rajesh (25132831)
Ben Jiwon Choi (25132834)
Claude Desplan (45436)
Cell Biology
Genetics
Neuroscience
Environmental Sciences not elsewhere classified
Biological Sciences not elsewhere classified
Developmental Biology
Cancer
Hematology
Plant Biology
innovative computational approach
genetic markers expressed
div >< p
subcellular mrna compartmentalization
optic lobe glia
two large single
detailed transcriptomic analysis
identify mrna species
glial diversity observed
adult visual system
glial cell bodies
glial cell types
understand glial development
visual system
cell mrna
cell bodies
glial types
glial cells
glia types
adult stages
cell class
cell atlas
neuropil glia
chiasm glia
work provides
transcriptionally appear
pupal stages
helps explain
gradually change
drosophila </
distinct mrnas
differentially localized
developmental trajectories
developmental single
comprehensively annotated
also present
allowed us
<p><b>(A)</b> UMAP embedding of isolated lamina neuropil glia integrated from all developmental stages (L3, P15, P30, P50, P70, and adult). Cells are colored by their stage of origin, showing the progressive divergence between epithelial and marginal glia fates (circled) through development. <b>(B)</b> UMAP-based subsetting of maturing lamina neuropil glial cells at the bifurcation (colored red) of epithelial and marginal glia adult fates. <b>(C)</b> Bar graph showing the proportion of red cells in (B) that belong to each developmental stage, showing that most cells at the fork belong to L3 and P15. <b>(D, D’)</b> UMAP-based trajectory selection (purple cells) illustrating maturation paths for medulla neuropil ALG and EG fates. <b>(E, E’)</b> Heatmap showing transcription factors with differential expression at early (right) mid (center) and late (left) pseudotime points for medulla neuropil EG (E) and medulla ALG glia (E’) developmental trajectories. The code used to generate the graphs can be found at <a href="https://zenodo.org/records/21890456" target="_blank">https://zenodo.org/records/21890456</a>.</p> <p>(TIFF)</p>
2026-09-28T17:57:37Z
Image
Figure
10.1371/journal.pbio.3004015.s003
https://figshare.com/articles/figure/_p_Comparison_of_lamina_and_medulla_glia_lineages_across_development_p_/34017622
CC BY 4.0