2026-10-14T10:06:28Z https://api.figshare.com/v2/oai

oai:figshare.com:article/34017437 2026-09-28T17:51:12Z category_1 category_12 category_13 category_14 category_46 category_734 category_61 category_64 portal_5 item_type_3 month_year_09_2026

<p>Genotype-specific differentially expressed genes (DEGs) under High Protein and Low Protein conditions.</p> Siyao Wang (1468693) Laura Childers (25132808) Fernando Martinez III (25132811) Michel Bagnat (3906664) Jieun Park (2560948) Biophysics Cell Biology Genetics Molecular Biology Immunology Biological Sciences not elsewhere classified Developmental Biology Cancer using transcriptome profiling uncover mechanisms underlying genetic analyses indicate wide transcriptional changes impairs lre differentiation low protein diet mutants exhibit upregulation homozygous mutants surviving div >< p poor survival due multiple generations resulted allele upon inbreeding zebrafish </ p dietary protein absorption transcriptional regulation lre endocytic dietary proteins protein malnutrition protein absorption pllp </ zebrafish loss survival rates study illustrates stable improvements specialized population rich enterocytes recurrent adaptation pllp ), organismal survival newly generated neonatal mammals natural selection mutant allele may contribute marked reduction intestinal function intestinal cells independently generated increased exposure immune genes environmental antigens enhanced survival absorptive activity <p>Lists of DEGs derived from cross-genotype comparisons that highlight distinct, non-overlapping transcriptional responses relative to the wild-type EK line. DEGs were identified using DESeq2 (padj < 0.05 and |LFC| > 1). The spreadsheet is organized into four distinct tabs: Tab 1 (genes_unique_to_1116_HP_table): Mutant-specific DEGs unique to the pd1116-/- line under High Protein (HP) conditions, containing genes that are significantly altered in the pd1116-/- vs. EK comparison but do not overlap with the pd1245-/- vs. EK dataset. Tab 2 (genes_unique_to_1116_LP_table): Mutant-specific DEGs unique to the pd1116-/- line under Low Protein (LP) malnutrition conditions, containing genes that are significantly altered in the pd1116-/- vs. EK comparison but do not overlap with the pd1245-/- vs. EK dataset. Tab 3 (genes_unique_to_1245_HP_table): Mutant-specific DEGs unique to the pd1245-/- line under High Protein (HP) conditions, containing genes that are significantly altered in the pd1245-/- vs. EK comparison but do not overlap with the pd1116-/- vs. EK dataset. Tab 4 (genes_unique_to_1245_LP_table): Mutant-specific DEGs unique to the pd1245-/- line under Low Protein (LP) malnutrition conditions, containing genes that are significantly altered in the pd1245-/- vs. EK comparison but do not overlap with the pd1116-/- vs. EK dataset. Each tab provides standard differential expression outputs, including gene symbols, base mean expressions, Log2 fold changes, standard errors, test statistics, p-values, and adjusted p-values. These partitioned lists correspond to the distinct genotype-specific sectors visualized in the Venn diagrams of <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1012071#pgen.1012071.s004" target="_blank">S2</a><a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1012071#pgen.1012071.s004" target="_blank">B</a>-<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1012071#pgen.1012071.s004" target="_blank">S2C Fig</a>.</p> <p>(XLSX)</p> 2026-09-28T18:02:07Z Dataset Dataset 10.1371/journal.pgen.1012071.s002 https://figshare.com/articles/dataset/_p_Genotype-specific_differentially_expressed_genes_DEGs_under_High_Protein_and_Low_Protein_conditions_p_/34017437 CC BY 4.0